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“In Aliquot #131, The Muscle and Bone Benefits of Creatine, creatine expert Dr. Darren Candow and I discussed how creatine supplementation affects muscle quality, physical function, and even skeletal health, particularly in older adults.”

“A wide array of toxicants, including heavy metals, such as cadmium and mercury; bisphenol A; polychlorinated biphenyls; and phthalate compounds, bioaccumulate in the human body. An individual's toxic burden may contribute to their poor metabolic function, inflammation, and cognitive dysfunction.”

“Time-restricted eating can help some people reduce eating opportunities, although a 12-month trial found no additional weight or body-fat benefit when an eight-hour eating window was added to calorie restriction. Sleep also affects appetite and fat distribution.”

“In this video, Dr. Darya & Kevin Rose talk about beta-hydroxybutyrate, an endogenous ketone body that increases in concentration during times of fasting or carbohydrate restriction. Beta-hydroxybutyrate also increases during a fasting-mimicking diet, which is a time of temporary period of calorie and protein restriction that generates many of the same biochemical effects of prolonged fasting.”

“A growing body of evidence suggests that sulforaphane's protective effects extend to the brain, where it appears to enhance brain-derived neurotrophic factor (a protein that controls and promotes the growth of new neurons) and inhibits histone deacetylation (an epigenetic modification that influences gene expression).”

“Exercise is essential in preventing age-related physical and mental decline. Sarcopenia, the loss of skeletal muscle tissue with age, is one of the most important causes of functional decline and loss of independence in older adults.”

“And one potential strategy for mitigating our risk for Alzheimer's disease as we age is a "cognoscopy" – a battery of assessments that measures some of the key biomarkers associated with the disease and can inform the trajectory of treatment.”

“Dr. Brooks pairs these relationships with practiced coping methods such as therapy, prayer, meditation, or journaling, creating a practical framework for meeting both everyday stress and major life changes.”

“Five grams of creatine per day increased total sleep duration on resistance-training days compared with placebo, while the groups did not differ in overall sleep quality. The result introduces sleep as a promising new area of creatine research.”

“Brief vigorous activity can add another training signal. In more than 25,000 adults who reported no leisure-time exercise, several one- to two-minute vigorous lifestyle bouts per day were associated with lower all-cause, cardiovascular, and cancer mortality during follow-up.”