Search results for circadian rhythm

“The gut-brain axis, the bidirectional signaling pathway between the gastrointestinal tract and the nervous system, modulates the body's stress response. A key player in this pathway is the gut microbiome, the collection of genomes of the microorganisms that exist in the gastrointestinal tract.”

“Sirtuins utilize NAD+ to remove specific chemical structures called acetyl groups – a process called deacetylation – from cellular proteins to control transcriptional regulation, energy metabolism, circadian rhythms, DNA repair, and cell survival.”

“Even neurotransmitters have circadian rhythms, and thus our problem-solving ability, alertness, and mood vary throughout the day. Cognitive performance typically peaks in a narrow window during the first half of the day and is also impacted by sleep.”

“SIRT1 has been shown to directly bind to CLOCK/BMAL1 to promote the deacetylation of BMAL1, thereby influencing its activity. Furthermore, SIRT1 can also promote the degradation of PER2, a protein that regulates circadian rhythms of metabolism, locomotor activity, and behavior.”

“Satchin's work deals specifically with the timing of food and its relationship with our biological clocks, which are governed by a circadian rhythm. "Mice that ate within a 12-hour time period had 70% less fat and 28% less total body mass.".”

“Evening room light can delay melatonin onset and shorten melatonin duration, while caffeine equivalent to a double espresso three hours before bedtime delayed circadian melatonin timing by about 40 minutes in a controlled study.”

“Circadian rhythms modulate a wide array of the body's physiological processes, ultimately influencing body weight, performance, and susceptibility to disease. Coordination of meal timing with the circadian rhythm can reduce markers of inflammation and affect aspects of metabolic health, including glucose regulation and insulin sensitivity.”

“Regular coffee drinkers consistently demonstrate a younger biological profile, with optimal effects seen around 2–3 cups daily, especially when consumed earlier in the day to align with our natural circadian rhythms.”

“Shift work creates a chronic disruption of circadian rhythms that affects sleep, metabolism, decision-making, and long-term health, often in ways people don't recognize until years later. In this Aliquot, joined by Drs.”