A Western diet impairs odor-related learning and memory in mice.
“These findings add to a growing number of studies investigating the role of diet and obesity in cognitive decline. The authors encourage future researchers to investigate the interactions between olfactory and endocrine systems in people with obesity and type 2 diabetes.”
Weighted vests may produce changes in body mass through perturbation of a homeostatic "gravitostat," a system regulating appetite by sensing weight
“In the 2020 study, the investigators conducted a randomized controlled trial involving 69 adults with mild obesity (body mass index of 30-35). About half of the participants wore a heavy weighted vest (11 percent of their body weight) for eight hours every day for three weeks, while the other half wore a light vest (1 percent of their body weight).”
Excess visceral fat promotes inflammation and drives cognitive decline.
“Excess visceral fat, often referred to as central or abdominal obesity, is a strong predictor of age-related cognitive decline. A new study in mice demonstrates that having excess visceral fat may impair cognition by activating the NLRP3 inflammasome and promoting the release of interleukin-1 beta (IL-1β).”
Obesity causes fat cells to die & release pieces of DNA that lead to inflammation & insulin resistance.
“People with higher than normal levels of visceral fat also had significantly higher levels of these pieces of DNA and this also associated with insulin resistance. Here is a press release for the study: http://medicalxpress.com/news/2016-03-results-cell-free-dna-involved-inflammation.html”
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