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“Exercise is a huge driver of how well we age because it induces profound molecular shifts that support immune health and might even protect our telomeres – indicators of aging. Exercise might help forestall certain age-related diseases, such as Parkinson's disease, too.”

“Researchers have determined that beta-hydroxybutyrate is an endogenous regulator of HDACs and is able to regulate age-related genes such as FOXO3. In this clip, Dr. Eric Verdin discusses the role of beta-hydroxybutyrate in protecting against oxidative stress, both as a nutrient, but also as a transcription regulator.”

“Cholesterol is vital to human health, but an oversimplified view of cholesterol — that high-density lipoprotein (HDL) cholesterol is good, and low-density lipoprotein (LDL) cholesterol is bad — has led to a gross misunderstanding of the nuances that define the differences in cholesterol-containing lipoproteins.”

“The mast cells release pro­inflammatory cytokines and proteases that damage the gut, leading to intestinal permeability, a condition otherwise known as “leaky gut.” This leakiness allows bacteria and bacterial antigens to cross the gut’s inner layer, the epithelium, and activate even more immune cells, leading to more inflammation – a key driver in the aging process.”

“A key component in these processes is the lactate shuttle – a metabolic pathway that facilitates the movement of lactate between tissues so it can be used as an energy source, effectively recycling it and supporting sustained exercise performance.”

“Exposure to environmental toxins – in the food we eat, the water we drink, and the air we breathe – is largely unavoidable. But monitoring our exposures and implementing diet and lifestyle strategies can help mitigate the risks associated with toxic exposures. In this Aliquot, Dr. Dale Bredesen, Dr. Michael Snyder, and I discuss ways to deal with our increasingly toxic environment.”

“But could aging become reversible in the future? Technologies like interrupted cellular reprogramming, in combination with future advances in the field of epigenetics, offer the promise that scientists may eventually be able to develop the means to reverse aging.”

“In this Aliquot, we share a variety of segments from different interviews covering some of the unconventional effects of omega-3 fatty acids and how to overcome some of the roadblocks to obtaining these effects.”

“Consuming chocolate and cocoa may carry some risks, however, due to their cadmium content and possible effects on the fetus during pregnancy. In this Aliquot, I describe some of the research on the benefits and risks of consuming cocoa and chocolate, as foods or supplements.”

“Preventing dementia requires a lifelong and multipronged approach that involves keeping inflammation (and its aging effects) at bay and making healthy lifestyle choices, such as exercising and consuming omega-3 fatty acids.”