Rapamycin
“Rapalog development Rapamycin is insoluble in water, so scientists have developed multiple classes of rapalogs—compounds that suppress mTOR but are readily absorbed and utilized by the body. These include everolimus, temsirolimus, zotarolimus, and ridaforolimus.”
Clip
Can an Apple Watch diagnose COVID-19? | Dr. Michael Snyder
“Detecting SARS-CoV-2 infection pre-symptomatically When the COVID-19 pandemic struck, Dr. Snyder's laboratory began investigating whether heart rate data might be able to inform SARS-CoV-2 infected people before symptoms arose, allowing them to get tested and self-quarantine.”
Clip
How Supplements May Support Brain Health With Age
“In this clip from Dr. Rhonda Patrick's appearance on The Tim Ferriss Show, she describes the supplements her parents use and separates a simple nutritional baseline from choices tied to individual health needs.”
Clip
How Exercise, Sleep, and APOE4 Shape Brain Aging
“APOE4 is the strongest common genetic risk factor for late-onset Alzheimer's disease, while physical activity, sleep, blood pressure, and diet remain important modifiable influences across the lifespan. Nutrition may offer additional support.”
Intestinal permeability
“One study found that avenin, unlike gluten, did not activate the pathways implicated in celiac disease development in cells in culture. In fact, a separate study conducted in rats found that oats improved gut leakiness caused by alcohol exposure.”
Episode
Dr. Matthew Walker on Sleep for Enhancing Learning, Creativity, Immunity, and Glymphatic System
“A key player in the development of Alzheimer's disease is amyloid-beta, a toxic protein that aggregates and forms plaques in the brain. Insufficient sleep increases the production of amyloid-beta, and amyloid-beta deposition, in turn, impairs sleep – in a vicious, self-perpetuating loop.”
Biological Age Clocks
“Then they combined selected DNAm protein surrogates, DNAm smoking pack-years, chronological age, and sex into a predictor of time-to-death. The main development and testing used the Framingham Heart Study Offspring cohort, with additional validation in several large cohorts.”
Alcohol
“Binge drinking levels of alcohol consumed prior to conception causes smaller offspring body weights and reduced pubertal and behavioral development, regardless of which parent was exposed to alcohol.”
Around 1 in 5 women have Polycystic Ovary Syndrome (PCOS) and new research shows young women with it up to 5x more likely to develop type 2 diabetes.
“"Crucially, obesity, a key trigger for type 2 diabetes, was not an important trigger in women with PCOS.". Often PCOS is undiagnosed. Symptoms can include irregular periods, weight gain, excessive facial hair and acne.”
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