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Dr. Rhonda Patrick discusses protein needs, choline in pregnancy, urolithin A, melatonin's benefits and risks, and creatine's effects on liver health.

“In a small randomized crossover trial, a single high dose of creatine improved selected cognitive outcomes during acute sleep deprivation, adding context for her interest in higher doses during travel or sleep loss.”

“In this video, Dr. Rhonda Patrick summarizes a recent study that found that frequency of sauna use was associated with increased decreased risk of death. Using the sauna 2-3 times per week was associated with 24% lower all-cause mortality and 4-7 times per week decreased all-cause mortality by 40%.”

“In a pooled analysis of 14 trials, supplementation averaging about two grams per day raised the mean Omega-3 Index from 4.9% to 8.1%, although individual responses varied with baseline status, dose, and formulation.”

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

“In this Aliquot, I'm joined by Drs. Martin Gibala, Luc van Loon, and Brad Schoenfeld to break down how to manage load, train in joint-friendly ways, reduce inflammation, and separate supplements supported by evidence from those that remain uncertain.”

“In humans, an analysis of 6,482 US adults associated higher fiber intake with lower serum concentrations of several persistent PFAS chemicals; the observational result does not prove that fiber caused clearance. Sauna is a different pathway, not a substitute for fiber.”

“In 15 people with severe traumatic brain injury, sodium lactate infusion increased brain lactate, pyruvate, and glucose without raising intracranial pressure, and a randomized study in 60 patients with mild traumatic brain injury reported better cognitive recovery than hypertonic saline.”

“Early human evidence includes local-heat studies during limb immobilization and biomarker studies after resistance training, but those results do not prove that whole-body sauna builds muscle or prevents age-related muscle loss.”

“Whereas fasting turns off multiple pathways associated with aging, such as mTOR, IGF-1, growth hormone, and others, eating for optimal fitness activates these important processes. This Aliquot features Drs. Guido Kroemer, Dominic D'Agostino, Valter Longo, Peter Attia, and Rhonda Patrick.”