Search results for mortality

“As a founding principal investigator at Altos Lab, Dr. Levine sits at the frontier of aging research, where she and her colleagues are investigating what she describes as some of the most exciting research in the field, centered on interrupted cellular reprogramming.”

“The largest practical gains often come from moving out of the lowest fitness categories. In a cohort of 122,007 adults referred for treadmill testing, higher cardiorespiratory fitness was associated with progressively lower long-term mortality, and the elite group had the lowest adjusted risk.”

“A separate cohort of 12,388 adults associated vitamin D exposure with 40 percent lower dementia incidence, and a 12-month randomized trial of 183 older adults with mild cognitive impairment found improvements on several cognitive tests with 800 IU per day.”

“Whereas fasting turns off multiple pathways associated with aging, such as mTOR and IGF-1, eating for optimal fitness activates these important processes. The IGF-1 pathway, in particular, plays key roles in growth and is strongly associated with cancer.”

“Wearable-device research in more than 25,000 adults who reported no structured exercise linked about three one- to two-minute vigorous bouts per day with substantially lower all-cause, cardiovascular, and cancer mortality.”

“A meta-analysis of seven randomized trials involving 182 participants found that high-intensity interval training improved flow-mediated dilation by 4.31%, compared with 2.15% after moderate-intensity continuous training, with a 2.26-percentage-point advantage between groups.”

“Some large cohorts have associated higher egg or dietary-cholesterol intake with greater cardiovascular events or all-cause mortality, while a meta-analysis of prospective studies found no significant association between higher egg intake and overall cardiovascular events.”

Hormesis is a compensatory defense response to a stressor that conditions the body against future stressors. Heat exposure – from sauna use, hot tubs, or eve...

“But what does the science say? In this Aliquot, Dr. Jed Fahey and I discuss the pros and cons of eating meat as well as the confounding factors that may influence the risks associated with meat consumption.”

“Insulin-like growth factor 1 (IGF-1) plays a role during childhood for growth and continues later in life to have anabolic and neurotrophic effects. IGF-1 is also implicated in contributing to aging and enhancing the growth of cancer after it has been initiated.”