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“Many people may find the prolonged fast too onerous, but the fasting-mimicking diet, an approach that recapitulates many of the same effects of prolonged fasting with a hyper-low calorie, low protein, higher fat diet stretched out over a longer interval of five days, may offer a more palatable strategy for activating autophagy.”

“In this first episode of the Aliquot podcast, Rhonda discusses topics such as her pre-pregnancy diet, exercise, and sleep; which supplements she included and avoided during pregnancy; the benefits of omega-3s and risk from mercury-containing fish; and nutrition for infants and toddlers that may positively influence brain development.”

“In a small randomized crossover trial, a single high dose of creatine improved selected cognitive outcomes during acute sleep deprivation, adding context for her interest in higher doses during travel or sleep loss.”

“An enriched marine-oil study produced time- and dose-dependent increases in specialized pro-resolving mediators and altered blood-cell responses over 24 hours; it tested biomarkers, not disease prevention. Exercise, sauna, and cruciferous vegetables act through different pathways.”

“Identifying the mechanisms that drive these correlations is an area of active research. Decreased carbohydrate intake results in reduced insulin signaling, and reductions in protein intake leads to decreased mTOR activation, two major aging pathways.”

“In this clip, Drs. Levine and Patrick discuss new advances in cellular aging research that show it's possible to reverse aging and generate new stem cells from already differentiated cells. Dr. Levine also discusses parabiosis, a treatment that involves giving old mice an infusion of plasma from young mice, and how it may reverse the cellular changes that accumulate during aging.”

“A recent finding in Dr. Elinav's lab suggests that smoking cessation-associated weight gain — a common complaint among people attempting to quit smoking — may be influenced by the gut microbiome. In this clip, Dr. Eran Elinav discusses generalizable ways to foster a healthy gut microbiome.”

“In a small trial of 30 people with stable heart failure, 1,000 milligrams twice daily approximately doubled whole-blood NAD and appeared tolerable while supporting further study rather than proving treatment benefit.”

“Microplastics are tiny plastic fragments that contaminate our food, water, and air, making exposure nearly unavoidable. Even healthy choices—such as brushing our teeth or drinking plenty of water—bring us into contact with vast amounts of microplastics.”

“The carnivore community is in error. Despite the overwhelming evidence demonstrating the beneficial health effects of isothiocyanates, some anti-nutritional effects of isothiocyanates have been reported.”