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“Recent discoveries in the field of aging research may have identified the signal that can manipulate the epigenome to restore proteins – including sirtuins – to their earlier, younger functional capacity.”

“The SCN, in turn, coordinates the body's peripheral clocks, such as those found in the liver, pancreas, muscles, and fatty tissue, driving rhythms of rest and activity that determine eating-fasting cycles.”

“Dr. Roland Griffiths is a clinical pharmacologist at Johns Hopkins and one of the world's foremost researchers on the psychedelic compound psilocybin. Learn more about Dr. Roland R. Griffiths Johns Hopkins Profile - Roland R. Griffiths. List of Publications.”

“Recognition of this phenomenon has given rise to the concept of biological age, sometimes referred to as phenotypic age, generally recognized as a measure of a person's physiological and functional state.”

“Although scientists have identified other lifestyle behaviors that can help prevent the build-up of amyloid plaques by boosting the capacity for glymphatic clearance – such as exercise and adequate intake of omega-3 – the most important factor by far is a good night's sleep, especially deep sleep.”

“Dr. Patrick discusses paraquat and rotenone because both can damage mitochondria and are used experimentally to model Parkinson-like neurodegeneration, but that rationale does not prove that either chemical caused disease in this population.”

“Air pollution leaves a biological fingerprint on our lungs, our blood vessels, and even our brains, eroding the body's defenses, triggering inflammation, weakening the blood-brain barrier, and accelerating cognitive decline.”

“In STEP 1, once-weekly semaglutide plus lifestyle support produced an average weight reduction of 14.9% over 68 weeks, compared with 2.4% with placebo, establishing strong efficacy for selected adults with overweight or obesity.”

“The gut-brain axis, the bidirectional signaling pathway between the gastrointestinal tract and the nervous system, modulates the body's stress response. A key player in this pathway is the gut microbiome, the collection of genomes of the microorganisms that exist in the gastrointestinal tract.”

“Telomeres have been likened to aglets – the little plastic caps on the ends of shoestrings that prevent the string from fraying – and it's a good analogy. Telomeres are distinctive structures comprised of short, repetitive sequences of DNA present on the ends of chromosomes.”