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“In later randomized trials, urolithin A improved some laboratory measures of muscle endurance or hamstring strength, but it did not significantly improve key primary outcomes such as six-minute walk distance, muscle ATP production, or peak power.”

“Dr. Patrick's practical answer is to use black coffee, a small amount of cream or MCT, or an unsweetened plant milk when frequent additions worsen the lipid tradeoff, and to assess ApoB rather than assume an additive is harmless.”

“Exercise is essential in preventing age-related physical and mental decline. Sarcopenia, the loss of skeletal muscle tissue with age, is one of the most important causes of functional decline and loss of independence in older adults.”

“The processes that mediate aging can be likened to those that drive the sharing of digital information – the idea that, as a signal is transmitted, information is lost and must be continually resent to maintain signal integrity.”

“Scientists have observed that the epigenetic clock of transplanted cells and their descendant lineages synchronize with the donor rather than the recipient, thus retaining the epigenetic age of the donor and remaining relatively unaffected by the cellular environment (the "niche") of the recipient.”

“Her practical approach is moderate and timing-focused. Dr. Patrick often uses a sauna or hot tub about two hours before bed and allows cooling to happen naturally, while her husband sometimes uses a cool shower.”

“Manipulation of cellular levels of NAD+ as a strategy for slowing aging "We’ve shown that NMN and others have shown for NR that it also helps with blood flow and actually mimics exercise and regrows the vascular system.” - David Sinclair, Ph.D. As we age, however, the NAD+ levels in our bodies decline, reducing resveratrol's potency.”

Dr. Rhonda Patrick explores growth hormone secretagogues, spermidine's longevity role, methylene blue, whey protein, and solutions for scar tissue in a Q&A.

“A special focus of this podcast, however, centers on Pierre's relationship with previous podcast guest Wim Hof, who is especially well-known for his extraordinary ability to withstand extreme cold, taking on many world records by doing so.”

“Some of the factors contributing to these variable phenotypes include persistent damage to our DNA and mitochondrial dysfunction, driven by an altered NAD:NADH ratio, the latter of which has recently been shown to be improved by certain dietary supplements like nicotinamide riboside.”