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“Manipulation of cellular levels of NAD+ as a strategy for slowing aging "We’ve shown that NMN and others have shown for NR that it also helps with blood flow and actually mimics exercise and regrows the vascular system.” - David Sinclair, Ph.D. As we age, however, the NAD+ levels in our bodies decline, reducing resveratrol's potency.”

“While it’s likely that there may be more going on with depression than just inflammation by itself, it could be an incredibly useful lens through which to look at promising avenues to potentially treat or prevent it, since controlling systemic inflammation shows promise as being both important for longevity and health in general.”

“Time-restricted eating – a term coined by Dr. Panda and his colleagues – has been adopted by the popular press as a form of intermittent fasting. It does not explicitly involve reducing calories but rather is an eating pattern wherein a person confines the time of day that they eat to a limited window and fasts for the remainder of the day.”

“In this clip, Drs. Levine and Patrick discuss definitions of aging used in science and why biological aging matters to scientists. Dr. Levine shares the hallmarks of aging that help researchers determine someone's biological age, what drives accelerated aging, and what epigenetic modifications such as CpG methylation say about the aging process.”

“In an early randomized workplace study, healthy employees who completed an eight-week mindfulness program showed a greater rise in antibodies after influenza vaccination than a waitlist group.”

“Other hormetic responses to cold exposure include increased production of PGC1-alpha, a protein that promotes mitochondrial biogenesis, the production of new, healthy mitochondria, and the activation of brown fat – a phenomenon once thought to occur only in newborns, but now known to occur in adults, especially after cold exposure.”

“In a small trial of 30 people with stable heart failure, 1,000 milligrams twice daily approximately doubled whole-blood NAD and appeared tolerable while supporting further study rather than proving treatment benefit.”

“Peak plasma flavan-3-ol metabolites after the banana smoothie were 84 percent lower than after the capsule, while the low-PPO berry smoothie produced levels similar to the capsule. PPO is released when plant tissue is cut, bruised, or blended and can react with selected polyphenols before they reach circulation.”

“And one potential strategy for mitigating our risk for Alzheimer's disease as we age is a "cognoscopy" – a battery of assessments that measures some of the key biomarkers associated with the disease and can inform the trajectory of treatment.”

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.