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“While exercise and caloric restriction have the potential to slow aging, rejuvenation has the potential to repair the damages associated with aging once they have occurred. In this clip, Dr. Eric Verdin explains how exercise and nutrition form the cornerstone of strategies to slow aging, but exciting approaches lie ahead.”

“In this clip, Dr. Rhonda Patrick describes the potential interaction between sulforaphane and iodine and stresses that iodine-deficient people or those with hypothyroidism should work with their physician to monitor thyroid hormone levels.”

“Autophagy is thought to be part of a coordinated biological process that is important for exposing cancer cells to the immune system, ultimately leading to their weakening and death. However, the relationship between autophagy and cancer is complicated.”

“Healthy, well-nourished adults can usually synthesize enough, and athlete trials have not found consistent improvements in immune measures, aerobic performance, body composition, or intestinal permeability from routine supplementation.”

“Therefore, researchers must rely on a combination of animal research and relevant biomarkers to estimate how alterations in lifestyle or diet affect human longevity. While both of these approaches have shortcomings, they remain the best tools available until new methodologies emerge.”

“Resveratrol is a "dirty molecule," however, known for its multiple cellular targets, so teasing out all the ramifications of its use has proven problematic. Furthermore, it is relatively unstable and demonstrates poor bioavailability in humans.”

“Vitamin D and a home exercise program added benefit on one clock. Separate analyses found lower odds of prefrailty and fewer invasive cancers with the full three-part intervention, making the combined healthy-aging approach a useful area for continued study.”

“Sulforaphane, an isothiocyanate compound derived from broccoli sprouts and certain cruciferous vegetables, exerts a wide range of beneficial effects in humans. Some of these effects are mediated by increased glutathione, one of the body's most potent antioxidants, to promote brain health.”

“Gaining FDA approval of psilocybin under these conditions is problematic, however, due to the negative connotations associated with the compound's use and the potential for harm when used in vulnerable populations.”

“Red yeast rice lowers LDL through monacolin K, which is chemically identical to lovastatin, so it shares statin-related mechanisms and requires attention to potency, contamination, medicine interactions, and muscle or liver effects.”