FoundMyFitness library
Ranked by shared topics.
“While aerobic exercise is often viewed preferentially through the lens of cardiovascular health, the diverse cascade of biological effects from exercise as a whole — and aerobic exercise, in particular — culminate to make it one of the most formidable and immediately practical real-world interventions for human aging and the brain.”
“Removing former drinkers from the non-drinker category reveals a different story: One study observed that the lowest risk for cardiovascular disease (i.e., ischemic heart disease) was right below one standard U.S. drink per week — men and women at this level of consumption had an ~18% lower risk compared to nondrinkers.”
“A mouse study demonstrated that oral berberine (50 or 100 mg/kg/bw per day) reversed the depression-inducing effects of corticosterone injection by upregulating hippocampal synthesis of brain-derived neurotrophic factor – a type of protein that acts on neurons in the central and peripheral nervous systems and may be important for the antidepressant response.”
“DAMPs such as HMG-1 bind to TLR4 and receptors for advanced glycation end products (RAGE) on cells at the blood-brain barrier to induce an immune response that initially inhibits the deposition of amyloid-beta, a key feature of Alzheimer's disease progression.”
“However, findings from a rodent study indicate that even low levels of nicotine exposure during pregnancy or early in life can increase the risk of sudden infant death syndrome, or SIDS, by inhibiting the neonate's ability to autoresuscitate – the capacity to recover from prolonged periods of apnea, widely considered a causal factor in SIDS.”
“Despite this, moderate consumption of foods like eggs—up to three per day—has not been shown to elevate plasma TMAO levels For optimal health, individuals should focus on meeting, but not greatly exceeding, the recommended daily intake of choline, ensuring they obtain it through a balanced diet rich in both animal and plant-based foods.”
“The analysis pooled data from 23 studies comprising 606 participants and determined the mean difference of neuromuscular performance (jump performance and sprint times), subjective measures of fatigue, muscle soreness, and biochemical markers, following either cold water immersion or passive recovery performed no less than 24-hours post-exercise stressor.”
“Creatine improves vascular health To investigate creatine's effects on blood vessel health—specifically by measuring the ability of arteries and small blood vessels to increase in size to accommodate blood flow (known as endothelial function)—one study recruited 12 healthy men and women with an average age of 59 and supplemented them with creatine or a placebo for 28 days each.”
“Neurogenesis Whereas the early view of the mammalian central nervous system presumed that it was a static complex incapable of change, a growing body of evidence suggests that it retains its capacity for synaptic pruning – the process that eliminates extra neurons and synaptic connections and establishes new neural circuits to increase the efficiency of neuronal transmissions – throughout life.”
“When we engage in high-intensity exercise, our muscles become mini biochemical laboratories, synthesizing compounds like lactate and myokines that circulate throughout the body and travel to our organs, where they exert a variety of signaling effects, including the synthesis of brain-derived neurotrophic factor (BDNF) in the brain.”