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“In addition, a randomized, placebo-controlled, double-blind trial involving people diagnosed with mild-to-moderate dementia due to Alzheimer's disease found that participants who took a resveratrol supplement twice a day (up to 1 gram) for one year exhibited reduced levels of MMP9, a neurological inflammatory marker associated with increased neurodegeneration and inflammation.”
“With such an important set of responsibilities, it is unsurprising that a decline in T cell-mediated immunity contributes to debilitating age-related illnesses: Reduced infectious immunity – Immunosenescence, a cellular process integral to thymic involution, is associated with reduced immunity to influenza and other respiratory infections and less effective response to influenza vaccination.”
“Just one month after their heart attack, participants assigned to 16:8 time-restricted eating experienced a 6.6% increase in a measure of their heart’s pumping efficiency known as left ventricular ejection fraction (LVEF) compared to a mere 1.5% increase in the regular diet group.”
Toll-like receptors are a family of pattern recognition receptors expressed on the surface of immune and other cells that play an important role in intestinal permeability and inflammaging.
“In a trial of middle-aged, low-fitness adults, urolithin A supplementation led to a 10–12% increase in lower-body muscle strength, a 10–15% increase in VO2 peak, and better performance on a 6-minute walk test, even when participants didn't engage in structured exercise training over the 4-month study.”
Intravenous Vitamin C for the treatment of sepsis Sepsis, a life-threatening condition that can arise due to the body's response to a bacterial or viral infection, can cause severe injury to multiple tissues or organs.(Source: CDC) (https://www.cdc.gov/sepsis/index.html) People diagnosed with sepsis typically have low vitamin C levels, which might be predictive of increased risk for organ failure.
“For example, exposure to ultraviolet B light is the primary source of vitamin D, but behaviors or characteristics that block or reduce sun exposure, such as using sunscreen, having high levels of melanin (a dark pigment found in skin that acts like natural sunscreen), exclusive breastfeeding, older age, or being obese can impair the skin's ability to produce vitamin D3.”