Related Episodes for Ultra-processed Foods (UPFs)

In this clip, Dr. Patrick explains how intense exercise beneficially alters tryptophan and kynurenine metabolism in a way that may benefit depression.

“The fact that poor sleep is linked with the aggregation of amyloid-beta plaques in the brain and Alzheimer's disease is not surprising. Although some strategies for improving the quality of sleep among people with Alzheimer's have been identified, this might be too late to turn the tide of cognitive decline.”

“Dr. Huberman’s practical range is deliberately cautious: not drinking avoids the exposure, and lower weekly intake creates less burden than a drink every night or heavier episodes.”

“Vasopressin, a pituitary hormone that acts to promote the retention of water by the kidneys and increase blood pressure, is also a social bonding hormone in males — similar to oxytocin in females. Tim recounts his experiences taking vasopressin in college to boost his short term memory.”

“Sulforaphane, an isothiocyanate compound derived from broccoli sprouts and certain cruciferous vegetables, exerts a wide range of beneficial effects in humans. Some of these effects are mediated by increased glutathione, one of the body's most potent antioxidants, to promote brain health.”

“A May 2025 Nature paper showed taurine uptake may fuel aggressive myeloid leukemias in laboratory and mouse models, illustrating how nutrients beneficial to healthy tissues may also feed certain cancers.”

“Mitochondria are best known for their energy-producing roles, but they also help regulate cellular metabolism, signaling, and apoptosis (programmed cell death). As a result, mitochondrial health is intrinsically linked to overall health.”

“Mitochondrial health and overall health are intrinsically linked. Identifying ways to boost mitochondrial biogenesis – the formation of new mitochondria – ensures that cells maintain an adequate number of mitochondria to meet their energy needs.”

“A key component in these processes is the lactate shuttle – a metabolic pathway that facilitates the movement of lactate between tissues so it can be used as an energy source, effectively recycling it and supporting sustained exercise performance.”

“In Aliquot #131, The Muscle and Bone Benefits of Creatine, creatine expert Dr. Darren Candow and I discussed how creatine supplementation affects muscle quality, physical function, and even skeletal health, particularly in older adults.”