Related Episodes for How stressed plants communicate to our genes (to our benefit) | David Sinclair

“Some of the factors contributing to these variable phenotypes include persistent damage to our DNA and mitochondrial dysfunction, driven by an altered NAD:NADH ratio, the latter of which has recently been shown to be improved by certain dietary supplements like nicotinamide riboside.”

“For a product-selection companion to these exposure-reduction strategies, read Dr. Patrick's analysis of how reliably “clean” labels describe finished personal-care and cleaning products. A nontargeted laboratory study found far more compounds than labels disclosed, but it did not measure absorbed dose or show that the tested products caused disease.”

“The mast cells release pro­inflammatory cytokines and proteases that damage the gut, leading to intestinal permeability, a condition otherwise known as “leaky gut.” This leakiness allows bacteria and bacterial antigens to cross the gut’s inner layer, the epithelium, and activate even more immune cells, leading to more inflammation – a key driver in the aging process.”

“While Dr. Rhonda Patrick’s first video focused primarily on the micronutrients found in the various fruits and vegetables she put in her smoothie, this one, in addition to offering some modest changes on the recipe, instead focuses on the beneficial “hormetic” compounds that are NOT micronutrients.”

“In a small immobilization trial, five grams per day of omega-3 fatty acids reduced the loss of muscle volume in young women compared with sunflower oil, supporting continued research on omega-3s and disuse atrophy. Heat is the fourth proposed tool.”

“The question of whether NAD+ is derived directly from NR or NMN in certain tissues rather than being salvaged from nicotinamide may, in particular, have implications for whether or not oral administration may be hampered in achieving maximal NAD+ status due to the fact that the process of salvaging NAD+ from nicotinamide is subject to feedback inhibition.”

“A randomized-trial meta-analysis found a higher atrial-fibrillation risk with marine omega-3 supplementation, with a stronger signal at doses above 1 gram per day; the included populations generally had cardiovascular disease or elevated cardiovascular risk.”

“EPA and DHA play particularly important roles in heart health because they participate in pathways involved in the production of hormones that regulate blood clotting and inflammation, help maintain healthy heart rhythms, and influence the contraction and relaxation of arteries.”

“01:36:35 - How increased muscle mass helps achieve lower blood sugar levels – reducing overall mortality – and the potential for suboptimal glycemic control long before doctors identify it. 01:52:28 - Peter's 80% zone 2 / 20% VO2 max training protocol.”

“The effects of heat exposure are broad and include improved immunity, better cardiovascular health, improved mood, and extended healthspan, the number of years we live in good health. Rhonda shares her personal sauna bathing routine and briefly describes special considerations for children and other special groups.”