Related Episodes for Dr. Charles Raison on Depression, the Immune-Brain Interface & Whole-Body Hyperthermia

“A smaller comparative study found improved hair density, shaft size, and anagen-follicle proportion with 2 percent ketoconazole shampoo, while its authors called for larger controlled studies. These results support individualized combinations rather than one universal protocol.”

“A small exploratory study detected some phthalates and metabolites in sweat, but it did not test sauna or exercise, show a fall in body burden, or establish clinical benefit. Reducing exposure remains the clearest practical strategy.”

“In a two-year trial of 237 postmenopausal women, approximately 9 to 10 grams per day combined with resistance training and walking did not add a bone-density benefit, so its role is better framed around muscle and physical function.”

“Patients assigned to supervised exercise during neoadjuvant chemoradiation, followed by continued activity before surgery, were more likely to achieve a complete or near-complete pathological response than those receiving usual care.”

“A larger randomized-trial meta-analysis also found modest average reductions in BMI, waist circumference, and body-fat percentage, although protocols and populations varied. These averages do not mean that HIIT alone guarantees fat loss.”

“The physical activity guidelines and estimates on how much activity we need are heavily based on self-reported activity, which is useful but imperfect: people remember going for a run, but they forget the short, intense bursts in daily life like sprinting up stairs, chasing kids, and running to catch a bus.”

“In this excerpt from Dr. Rhonda Patrick's A4M LongevityFest 2023 keynote, she argues that vigorous exercise is one of the most powerful tools for healthy aging because it can raise cardiorespiratory fitness.”

“In 25,241 adults who reported no structured exercise, a median of three one- or two-minute vigorous lifestyle bouts per day was associated with 38% to 40% lower all-cause and cancer mortality and 48% to 49% lower cardiovascular mortality.”

“Controlled human studies support acute brain-related responses to high-intensity exercise. Six short all-out cycling intervals improved selected learning and executive measures while increasing circulating BDNF, IGF-1, and VEGF; lactate tracked several of these changes.”

“The end result is an upside-down sleep schedule in which circadian rhythms and gene expression in the body become desynchronized. In this clip, Dr. Satchin Panda describes the effects of inappropriate light signals and discusses strategies to mitigate their effects.”