Related Episodes for Dr. Charles Raison on Depression, the Immune-Brain Interface & Whole-Body Hyperthermia

“- Arthur Brooks, Ph.D. The episode closes with a framework from Brooks's work on the second half of life: jump, serve, worship, and connect, a framework he outlines in one of his earlier books, From Strength to Strength: "Jump" means proactively building the next thing, especially during liminal periods or unwelcome change, which Brooks sees as fertile ground for creativity.”

“Since a driving force in the development of insomnia is change, especially change that affects relationships, employment, or family dynamics, Dr. Mason employs cognitive behavior techniques that help her patients identify what those changes are and develop strategies that promote, rather than hinder, sleep.”

“- Practical details like temperature and duration of sauna use, the difference between a dry, wet and infrared sauna, sauna timing, as well as other forms of heat stress such as steam showers, hot baths, and hot yoga.”

“Dr. Patrick begins with a prospective Finnish cohort in which men reporting four to seven sauna sessions per week had lower dementia and Alzheimer's disease incidence than men reporting one session. The study is observational, male-only, and cannot prove that sauna caused the lower risk.”

“Bright light exposure has a profound effect on regulating the circadian system in humans. Dr. Panda and colleagues discovered that melanopsin — a light-sensitive protein found in specialized cells of the eye — responds to blue light and synchronizes the body's day/night cycle.”

“Disruption of a person’s chronotypic schedule can influence mood, productivity, and disease risk because it may interfere with the duration of their REM sleep, which is essential for emotional well-being.”

“Reducing inflammation may be beneficial for a variety of physical and mental conditions. In this clip, Wim Hof shares his personal story that led to his passionate pursuit of how we can harness the body's innate ability to heal itself.”

“Other hormetic responses to cold exposure include increased production of PGC1-alpha, a protein that promotes mitochondrial biogenesis, the production of new, healthy mitochondria, and the activation of brown fat – a phenomenon once thought to occur only in newborns, but now known to occur in adults, especially after cold exposure.”

“Activity in the default mode network (DMN), a group of interacting brain regions implicated in self-related thinking, rumination, and depression, is suppressed by psilocybin and other psychedelic substances.”

“Dr. Patrick describes increased shear as a possible way vigorous exercise can damage fragile circulating tumor cells; this is a proposed mechanism, not proof that a workout eliminates metastasis or treats an established tumor.”