Related Episodes for Default mode network is suppressed by meditation practice | Roland Griffiths

“A systematic review found no overall improvement in mood after cold-water immersion, while a small randomized trial found that repeated whole-body cryotherapy improved depression scores when added to standard pharmacological treatment.”

“Mouse studies of feeding during infection also found different responses across bacterial and viral models, so a minimally processed dietary pattern, regular exercise, and normal hydration and nutrition during illness provide a more useful foundation than one universal food or fasting rule.”

“Meal composition can shape the body's short-term metabolic response. In this clip from Dr. Rhonda Patrick's appearance on Huberman Lab, she and Dr. Andrew Huberman discuss how large, highly processed, or saturated-fat-rich meals may affect gut-derived signals, energy, and mood.”

“Dr. Rhonda Patrick discusses how conditioning the body to heat stress through sauna use, called "hyperthermic conditioning" may cause adaptations that increase athletic endurance (by increasing plasma volume and blood flow to heart and muscles) and potentially even muscle mass. She also discusses the profound effects of hyperthermic conditioning on the brain including cognitive function.”

“While it’s likely that there may be more going on with depression than just inflammation by itself, it could be an incredibly useful lens through which to look at promising avenues to potentially treat or prevent it, since controlling systemic inflammation shows promise as being both important for longevity and health in general.”

“Among the 12 participants who completed the final assessment in this single-arm feasibility study, the mean Beck Depression Inventory-II score fell by 15.8 points, and 11 no longer met criteria for major depressive disorder.”

“Circulating LPS can also bind to lipoproteins, facilitating their absorption in the liver during LDL recycling, effectively removing LPS from circulation and lowering systemic inflammation – a phenomenon demonstrated mechanistically with statins that increase lipoprotein recycling by increasing LDL receptors.”

“00:34:40 - Repeated traumatic brain injury has cumulative neuroinflammatory effects in the brain over years, including amyloid-beta plaque and tau tangle formation. Study. 00:44:00 - A variant of the APOE gene increases risk of developing Alzheimer’s disease as much as 15-fold.”

“New Scientist article. 02:06:10 - Some people, like Tom Cruise and Keanu Reeves, seem to defy aging. 02:08:15 - One 12-ounce can of sugar-sweetened soft drink per day shortened telomere length, corresponding to 4.6 years of biological aging.”

“People who have poor cardiorespiratory fitness are more likely to be depressed. Sauna improves cardiorespiratory fitness and may offer a means to ameliorate the symptoms of depression and improve mood. In this clip, Drs. Rhonda Patrick and Jari Laukkanen discuss the benefits of sauna use in terms of cardiorespiratory fitness and mood.”