Related Episodes for Growth hormone defect protects against cancer, diabetes, and cognitive decline | Valter Longo

“In later randomized trials, urolithin A improved some laboratory measures of muscle endurance or hamstring strength, but it did not significantly improve key primary outcomes such as six-minute walk distance, muscle ATP production, or peak power.”

“Large treadmill cohorts associate higher measured fitness with lower mortality, while a 46-year study of middle-aged men linked the highest fitness category with about 4.9 additional estimated life-years compared with the lowest category.”

“There's a lot of exciting research right now into aging and maximum lifespan, but scientists have really just scratched the surface of the fascinating topic of how to live longer, healthier lives. Relevant Publications Rootzén, Holger, and Dmitrii Zholud.”

“Dr. Rhonda Patrick discusses how conditioning the body to heat stress through sauna use, called "hyperthermic conditioning" may cause adaptations that increase athletic endurance (by increasing plasma volume and blood flow to heart and muscles) and potentially even muscle mass. She also discusses the profound effects of hyperthermic conditioning on the brain including cognitive function.”

“In this talk, we’ll be exploring the intersection between genetics, nutrition, and environment: how your diet, micronutrients, exercise, heat stress, and sleep can change the expression of your genes and how this has profound effects on the way your body functions and ages.”

Many of the anabolic effects of growth hormone are thought to be mediated by insulin-like growth factor-1, or IGF-1 (https://www.ncbi.nlm.nih.gov/pubmed/18500379), which is synthesized primarily in the liver but also in skeletal muscle in response to growth hormone.

“Study. 01:43:00 - High animal protein intake was only positively associated with cardiovascular mortality among individuals with at least one unhealthy lifestyle risk factor, such as obesity or sedentary lifestyle. Study.”

“00:29:20 - Organs shrink during fasting and then regrow after refeeding. Study. 00:29:45 - Fasting stresses healthy cells so they increase their stress-response pathways, including heat shock proteins, antioxidant production, and anti-inflammatory.”

“02:03:18 - A recent study measured omega-3 fatty acid levels from both supplemental and dietary sources in blood and found that for every 1 percent increment in omega-3 fatty acid levels there was a 20 percent decreased risk in all-cause mortality.”

“Some of the factors contributing to these variable phenotypes include persistent damage to our DNA and mitochondrial dysfunction, driven by an altered NAD:NADH ratio, the latter of which has recently been shown to be improved by certain dietary supplements like nicotinamide riboside.”