Related Episodes for Whole-body hyperthermia as a treatment for depression: sauna, hot yoga and exercise | Charles Raison

“In this excerpt from Dr. Rhonda Patrick's A4M LongevityFest 2023 keynote, she argues that vigorous exercise is one of the most powerful tools for healthy aging because it can raise cardiorespiratory fitness.”

“In 25,241 adults who reported no structured exercise, a median of three one- or two-minute vigorous lifestyle bouts per day was associated with 38% to 40% lower all-cause and cancer mortality and 48% to 49% lower cardiovascular mortality.”

“Controlled human studies support acute brain-related responses to high-intensity exercise. Six short all-out cycling intervals improved selected learning and executive measures while increasing circulating BDNF, IGF-1, and VEGF; lactate tracked several of these changes.”

“The end result is an upside-down sleep schedule in which circadian rhythms and gene expression in the body become desynchronized. In this clip, Dr. Satchin Panda describes the effects of inappropriate light signals and discusses strategies to mitigate their effects.”

“Studies of centenarians suggest that lower levels of inflammation are associated with longevity. Different types of fiber provide fuel to diverse species of bacteria in the gut, which then synthesize byproducts that regulate the inflammatory process.”

“In this clip, Drs. Levine and Patrick discuss genetic and environmental factors that can accelerate or slow epigenetic aging. Dr. Levine also discusses the aging clock she created and how it can be used, along with other biomarkers, to determine an individual's rate of aging.”

“Evidence continues to emerge that illustrates that the fasting-mimicking diet, particularly its ability to cause immune cell turnover, may provide beneficial effects in the treatment of auto-immune diseases such as multiple sclerosis.”

“In a clinical trial, researchers subjected people to three cycles of a fasting-mimicking diet and measured biomarkers including cholesterol, triglycerides, fasting glucose, IGF-1, blood pressure, and C-reactive protein.”

“A large meta-analysis found that protein supplementation improved resistance-training gains in muscle size and strength, with little additional lean-mass benefit above an estimated total intake of about 1.6 grams per kilogram per day for most participants.”

“When produced during exercise (especially high intensity workouts like cycling, which shifts metabolism toward glycolysis to more quickly meet the high energetic demands), lactate switches on more than 600 genes involved in muscle adaptation, stimulates mitochondrial biogenesis – the process of making new mitochondria – and promotes protein synthesis, which is essential for muscle growth.”