Related Episodes for Joe Rogan Experience #502 - Dr. Rhonda Patrick

“When produced during exercise (especially high intensity workouts like cycling, which shifts metabolism toward glycolysis to more quickly meet the high energetic demands), lactate switches on more than 600 genes involved in muscle adaptation, stimulates mitochondrial biogenesis – the process of making new mitochondria – and promotes protein synthesis, which is essential for muscle growth.”

“How too much iron can lead to protein aggregation and how vitamin D can prevent it. A program, directed by Gordon, called the Caenorhabditis Intervention Testing Program which tests potential longevity compounds that may extend the lifespan of several different species of worms.”

“In this clip from Dr. Rhonda Patrick's appearance on The Mel Robbins Podcast, she outlines a practical sleep audit built around adequate sleep, morning light, regular timing, earlier meals, and alcohol awareness.”

“Earlier long-term research in older male physicians found no cognitive benefit, and the main COSMOS trial did not significantly reduce invasive cancer, cardiovascular events, or mortality over a median of 3.6 years.”

“A later crossover study using a lower weight-based dose found its clearest benefit in reasoning, while several memory, accuracy, fatigue, and sleepiness outcomes did not reliably improve. Routine muscle supplementation and acute sleep-loss research use different protocols.”

“Although many seed vendors provide quality seeds that are free of pesticides and have high germination rates, determining the glucoraphanin content in broccoli seeds requires laboratory analysis that may be cost-prohibitive for most home growers.”

“This is a proposed metabolic advantage, not proof of slower brain aging. Small TBI trials found that sodium lactate lowered intracranial pressure more than mannitol in severe TBI and improved cognitive scores more than 3% sodium chloride in mild TBI.”

“During about eight years of follow-up, the models associated one vigorous minute with roughly 4.1 moderate minutes for all-cause mortality, 7.8 minutes for cardiovascular mortality, and 9.4 minutes for type 2 diabetes risk.”

“Mouse studies of feeding during infection also found different responses across bacterial and viral models, so a minimally processed dietary pattern, regular exercise, and normal hydration and nutrition during illness provide a more useful foundation than one universal food or fasting rule.”

“Whereas fasting turns off multiple pathways associated with aging, such as mTOR and IGF-1, eating for optimal fitness activates these important processes. The IGF-1 pathway, in particular, plays key roles in growth and is strongly associated with cancer.”