Related Episodes for Resveratrol improves aortic stiffness (in rhesus monkeys) | David Sinclair

“There's a lot of exciting research right now into aging and maximum lifespan, but scientists have really just scratched the surface of the fascinating topic of how to live longer, healthier lives. Relevant Publications Rootzén, Holger, and Dmitrii Zholud.”

“Dr. Rhonda Patrick discusses how conditioning the body to heat stress through sauna use, called "hyperthermic conditioning" may cause adaptations that increase athletic endurance (by increasing plasma volume and blood flow to heart and muscles) and potentially even muscle mass. She also discusses the profound effects of hyperthermic conditioning on the brain including cognitive function.”

“In this talk, we’ll be exploring the intersection between genetics, nutrition, and environment: how your diet, micronutrients, exercise, heat stress, and sleep can change the expression of your genes and how this has profound effects on the way your body functions and ages.”

“Insulin-like growth factor 1 (IGF-1) plays a role during childhood for growth and continues later in life to have anabolic and neurotrophic effects. IGF-1 is also implicated in contributing to aging and enhancing the growth of cancer after it has been initiated.”

Many of the anabolic effects of growth hormone are thought to be mediated by insulin-like growth factor-1, or IGF-1 (https://www.ncbi.nlm.nih.gov/pubmed/18500379), which is synthesized primarily in the liver but also in skeletal muscle in response to growth hormone.

“Study. 01:43:00 - High animal protein intake was only positively associated with cardiovascular mortality among individuals with at least one unhealthy lifestyle risk factor, such as obesity or sedentary lifestyle. Study.”

“01:52:55 - Environmental enrichment creates epigenetic changes that benefit learning and memory in rodents and these benefits transfer to offspring. Study. 02:05:00 - NASA study showed that gravity influenced expression of genes involved in metastasis.”

“02:03:18 - A recent study measured omega-3 fatty acid levels from both supplemental and dietary sources in blood and found that for every 1 percent increment in omega-3 fatty acid levels there was a 20 percent decreased risk in all-cause mortality.”

“Some of the factors contributing to these variable phenotypes include persistent damage to our DNA and mitochondrial dysfunction, driven by an altered NAD:NADH ratio, the latter of which has recently been shown to be improved by certain dietary supplements like nicotinamide riboside.”

“A later Framingham analysis followed 2,240 adults for 11 years and found that a red-cell fatty acid model including the Omega-3 Index predicted all-cause mortality about as well as a model using several standard cardiovascular risk factors.”