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Related Episodes for The relationship between sleep and insulin sensitivity | David Sinclair

Ranked by shared topics, with one result from each original episode.

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Aliquot #133: The Surprising Effects of Creatine on the Brain

Aug 15, 2025

“In Aliquot #131, The Muscle and Bone Benefits of Creatine, creatine expert Dr. Darren Candow and I discussed how creatine supplementation affects muscle quality, physical function, and even skeletal health, particularly in older adults.”

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Aliquot #137: How to Optimize Iron without Causing Overload

Oct 24, 2025

“In this Aliquot, I'll explore how to recognize and address iron deficiency, the unique challenges of iron overload in aging, the ways alcohol may influence brain iron, and how infants tightly regulate iron as a built-in defense against infection.”

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Aliquot #144: How to Slow Joint Degeneration

Feb 27, 2026

“In this Aliquot, I'm joined by Drs. Martin Gibala, Luc van Loon, and Brad Schoenfeld to break down how to manage load, train in joint-friendly ways, reduce inflammation, and separate supplements supported by evidence from those that remain uncertain.”

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Aliquot #148: The Hype and Reality of Nicotinamide Riboside

Jul 13, 2026

“In this Aliquot, I walk through how that plays out in humans, where the strongest evidence shows up, and where it doesn't, with NAD researcher Dr. Charles Brenner—and why I'm taking it now after being skeptical.”

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Duration: 45m 35s
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Aliquot #15: Autophagy: A cellular recycling program with implications for health and longevity

Dec 31, 2020

“Modulating autophagy – through fasting and exercise (which both increase acetyl CoA) or intake of nutrients like spermidine – represents a promising therapeutic approach for extending human lifespan and healthspan.”

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Aliquot #150: Can Urolithin A Renew Aging Mitochondria?

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“It has attracted interest for its potential to activate mitophagy, the process cells use to clear out damaged mitochondria. In this Aliquot, I explain why mitochondrial cleanup matters for aging, why urolithin A production varies, and what early human studies suggest about its potential benefits.”

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Duration: 23m 9s
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Aliquot #152: How to Counteract a Sedentary Workday

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“A more useful approach is to focus on what you can do to reduce its effects. In this Aliquot, Dr. Kelly Starrett explains why standing more is not enough, how to build movement into your workday, and why it matters for long-term mobility.”

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Aliquot #16: Time-restricted eating for better metabolic health, part 1

Jan 6, 2021

“Time-restricted eating, which involves taking in food within a small window of time during the day and fasting for the remainder, can improve certain biomarkers of health – even without weight loss – to improve overall health. In Part I of this two-part segment, Drs.”

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Aliquot #17: Time restricted eating for better metabolic health, part 2

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“Coordination of meal timing with the circadian rhythm can reduce markers of inflammation and affect aspects of metabolic health, including glucose regulation and insulin sensitivity. Animal studies suggest that overnight fasting induces autophagy.”

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Aliquot #18: The dual nature of IGF-1: Striking a balance for optimal health

Jan 26, 2021

“Insulin-like growth factor-1, or IGF-1 for short, is a protein that plays critical roles in major growth pathways in the human body. It influences nearly every tissue in the body, especially developmental growth, skeletal muscle and neurons.”

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Duration: 34m 49s
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