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“According to the latest research on fed vs. fasted exercise: If your workout lasts longer than 60 minutes, especially aerobic (endurance-based) sessions, eating beforehand tends to improve performance Your body has quick access to glucose, which helps you go longer and harder.”

“Regulating the amount of light in our environment is crucial for a good night's sleep and a good mood the next day. Habits such as using blue light-emitting electronics close to bedtime can reduce melatonin production by as much as 20 percent, impairing sleep.”

“In an observational cohort of 2,545 couples undergoing IVF, women who consumed at least four drinks per week had lower live-birth odds, as did couples in which both partners consumed at least four drinks per week.”

“Dr. Patrick begins with a prospective Finnish cohort in which men reporting four to seven sauna sessions per week had lower dementia and Alzheimer's disease incidence than men reporting one session. The study is observational, male-only, and cannot prove that sauna caused the lower risk.”

“The Mediterranean diet pattern is rich in micronutrient-dense foods such as vegetables, fish, and olive oil and has been shown to reduce the risk of cardiovascular disease and other major causes of death.”

“Measuring 25-hydroxyvitamin D helps place these factors in context. When sunlight is insufficient, Dr. Patrick favors vitamin D3 over vitamin D2 and stresses that dose should match the person rather than follow a universal rule.”

“Many people may find the prolonged fast too onerous, but the fasting-mimicking diet, an approach that recapitulates many of the same effects of prolonged fasting with a hyper-low calorie, low protein, higher fat diet stretched out over a longer interval of five days, may offer a more palatable strategy for activating autophagy.”

“Dr. Michael Grandner describes this as the "mind after midnight"— being awake past our normal bedtime biases us toward reward-seeking, negative affect, and weaker executive control, helping explain not only late-night eating (a preference for energy-dense, high-fat, and high-sugar foods) but other impulsive behaviors that occur at this time.”

“Poor sleep reduces the body's insulin sensitivity and changes a person's appetite, increasing the preference for high carbohydrate foods like pizza, pasta, and sweets. Lack of sleep also alters the gut microbiota and impairs immunity, putting us at risk for developing acute illnesses like colds and flu.”

“Liberalizing the diet by altering protein, fat, and fiber intake may make the diet more tolerable. For those who have difficulty reaching and sustaining ketosis, ketone supplementation may be beneficial, but their use might interfere with weight loss.”