Search results for insulin resistance

“The revelation that 70% of FDA drugs are subject to circadian effects and are either less effective or more effective at certain times of the day. The effect melatonin has on the pancreatic production of insulin and the insight this lends to why we should probably stop eating at least 2-3 hours before we go to bed.”

“General principles of resistance training—as outlined by Dr. Layne Norton—include consistency, progressive overload, recovery, and mindset. Training for Strength, Hypertrophy, and Body Recomposition Training for muscle strength involves heavy loads (≥85% of 1 rep max) and low reps (1-5 per set).”

“Refined and starchy carbohydrate excess can worsen insulin resistance and triglyceride-rich VLDL export; VLDL is a major precursor of LDL. Saturated fat can increase cholesterol synthesis and reduce hepatic LDL-receptor-mediated clearance, although individual responses vary greatly.”

“Combining aerobic and resistance exercise provides a broad approach to body composition and metabolic function, including during and after the menopause-related shift toward greater abdominal fat storage.”

Dr. Rhonda Patrick discusses fragmented sleep, lipid biomarkers including ApoB and LP(a), coffee makers and bean quality, and choline supplementation.

“A lesser-known contributor is anabolic resistance, the reduced sensitivity to a given protein dose that promotes muscle building. Dr. Phillips describes studies in his laboratory suggesting that inactivity is a driver of anabolic resistance.”

“But with their rise in popularity come important questions about long-term effects and safe use. In this Aliquot, I discuss how these drugs work, their pros and cons, the latest research, and lifestyle strategies to optimize their effects for long-term health.”

“This supports Dr. Patrick's point that the eating window must still contain enough total protein and a strong muscle-building stimulus. Morning protein can be especially useful for older adults, who often eat less protein at breakfast and experience anabolic resistance.”

“In this member Q&A clip, Dr. Rhonda Patrick explains the incretin hormones GIP and GLP-1. GLP-1 receptor agonists such as semaglutide increase glucose-dependent insulin signaling, reduce glucagon, slow gastric emptying, and act on appetite pathways in the brain.”

“Human imaging research associates stronger hypothalamic insulin responsiveness with less visceral fat and better long-term weight-loss maintenance. A separate randomized inpatient trial helps place the five-day experiment in a broader dietary context.”