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“Manipulation of cellular levels of NAD+ as a strategy for slowing aging "We’ve shown that NMN and others have shown for NR that it also helps with blood flow and actually mimics exercise and regrows the vascular system.” - David Sinclair, Ph.D. As we age, however, the NAD+ levels in our bodies decline, reducing resveratrol's potency.”

Dr. Rhonda Patrick discusses joint aging prevention, avoiding heavy metals in protein, reducing migraines, nicotinamide for skin, and minimizing jet lag.

Dr. Rhonda Patrick discusses GLP-1 agonists, alpha-lipoic acid, ubiquinone vs. ubiquinol, calcium needs, and liquid biopsy cancer screening.

“Supplementing with oral DHEA (usually 25–50 mg per day) can meaningfully boost testosterone levels, potentially improving symptoms like low energy, quality of life, and libido; however, limited evidence exists for improvements in menopausal symptoms, sexual function, cognition, or overall well being in normal women without adrenal insufficiency.”

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

“- Arthur Brooks, Ph.D. The episode closes with a framework from Brooks's work on the second half of life: jump, serve, worship, and connect, a framework he outlines in one of his earlier books, From Strength to Strength: "Jump" means proactively building the next thing, especially during liminal periods or unwelcome change, which Brooks sees as fertile ground for creativity.”

“For instance, while the U.S. has high obesity rates, its rates of type 2 diabetes remain modest compared to countries like Singapore, India, and many Middle Eastern nations—populations that, on average, tend to have "fatter fat cells" and therefore develop metabolic complications at lower body mass indices (BMIs).”

“Study. 01:43:00 - High animal protein intake was only positively associated with cardiovascular mortality among individuals with at least one unhealthy lifestyle risk factor, such as obesity or sedentary lifestyle. Study.”

“BFR training protocols include a frequency of 2-3 times per week, occlusion pressure of 40-80% depending on the limb, using 2 exercises per muscle group, repetition schemes, wear times of 10-20 minutes, loads of 20-50% of 1 rep max, and a tempo of 1-2 seconds for both concentric and eccentric.”

“The mast cells release pro­inflammatory cytokines and proteases that damage the gut, leading to intestinal permeability, a condition otherwise known as “leaky gut.” This leakiness allows bacteria and bacterial antigens to cross the gut’s inner layer, the epithelium, and activate even more immune cells, leading to more inflammation – a key driver in the aging process.”