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“Perhaps the most clear-cut examples of cryotherapy’s beneficial effects are observed in the brain, where levels of the hormone and neurotransmitter norepinephrine – responsible for vigilance, attention, focus, and positive mood – increase markedly when the body is exposed to extreme cold.”

“Dr. Patrick recommends bounded quality checks such as GMP manufacturing and independent testing; she notes that some tested products were below their stated heavy-metal limits, not that lion’s mane products are uniformly contaminated.”

“Hormesis is a compensatory defense response to a stressor that conditions the body against future stressors. Cold exposure, a powerful hormetic stressor, activates the body's cold shock response, the goals of which are simple: to reduce heat loss and increase heat production.”

“Nearly half of all adults in the United States have high blood pressure, defined as having a systolic pressure of 130 mmHg or higher or a diastolic pressure of 80 mmHg or higher. Maintaining early healthy blood pressure is critical to ensuring the proper functioning of blood vessels in the brain and blood-brain barrier integrity.”

“Resistance training is one of the most effective ways to maintain bone health. Still, other lifestyle factors, like not smoking, limiting alcohol, and ensuring that you provide your body with the nutritional components it needs for bone-building, are important too.”

“Whether the medical community will embrace these lifestyle interventions remains to be seen. Available pharmaceutical treatments have their advantages and disadvantages, and while they are helpful for a subset of depressed people, a quarter of patients taking antidepressants may get worse.”

Dr. Rhonda Patrick discusses stroke risk, eczema, immune resilience, her new smoothie recipe, and whether everyone should cut out gluten.

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

“Vasopressin, a pituitary hormone that acts to promote the retention of water by the kidneys and increase blood pressure, is also a social bonding hormone in males — similar to oxytocin in females. Tim recounts his experiences taking vasopressin in college to boost his short term memory.”

“A growing body of evidence suggests that exogenous lactate or beta-hydroxybutyrate may be useful in the treatment of traumatic brain injury. These compounds allow glucose to be spared as an energy source and instead be utilized in the synthesis of the antioxidant glutathione, which is vital following a brain injury.”