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Dr. Rhonda Patrick discusses cancer prevention, linoleic acid, shingles vaccine and dementia, creatine's kidney effects, and shares her overnight oats recipe.

“These changes increase infection risk, weaken vaccine responses, and reduce early cancer surveillance. Yet immune aging is not fixed. Movement, sleep, stress regulation, temperature exposure, and nutrition shape immune cell balance and inflammatory activity over time.”

“Inflammation, a downstream consequence of insulin resistance, promotes the formation of reactive oxygen species and other damaging molecules, which can enter the brain via the lymphatic system.”

“In this clip, Drs. Levine and Patrick discuss genetic and environmental factors that can accelerate or slow epigenetic aging. Dr. Levine also discusses the aging clock she created and how it can be used, along with other biomarkers, to determine an individual's rate of aging.”

“Many people may find the prolonged fast too onerous, but the fasting-mimicking diet, an approach that recapitulates many of the same effects of prolonged fasting with a hyper-low calorie, low protein, higher fat diet stretched out over a longer interval of five days, may offer a more palatable strategy for activating autophagy.”

“Late-night eating can have negative effects on our health. But time-restricted eating limits the daytime window during which a person eats to take advantage of the time when metabolism is optimized, improving health and even promoting weight loss.”

“In this Aliquot, I'm joined by Drs. Martin Gibala, Luc van Loon, and Brad Schoenfeld to break down how to manage load, train in joint-friendly ways, reduce inflammation, and separate supplements supported by evidence from those that remain uncertain.”

“A key component in these processes is the lactate shuttle – a metabolic pathway that facilitates the movement of lactate between tissues so it can be used as an energy source, effectively recycling it and supporting sustained exercise performance.”

“Vinegar and berberine may modestly change glycemic measures, but the larger practical point is that substrate levels and signaling molecules must be interpreted together, with medication interactions and hypoglycemia risk considered.”

“00:29:20 - Organs shrink during fasting and then regrow after refeeding. Study. 00:29:45 - Fasting stresses healthy cells so they increase their stress-response pathways, including heat shock proteins, antioxidant production, and anti-inflammatory.”