Search results for butyrate

Dr. Eric M. Verdin discusses the roles of the ketogenic diet, beta-hydroxybutyrate, HDAC inhibitors, NAD+, and more in the context of aging.

“Dietary fiber is a broad term that refers to the non-digestible components of fruits and vegetables. Gut microbes break down certain types of fiber, releasing micronutrients trapped in the fiber matrix and producing beneficial metabolic byproducts, such as short-chain fatty acids.”

“As a prominent researcher and long-term follower of the ketogenic diet, Dr. D'Agostino believes that while someone can survive without fruits and vegetables, this dietary pattern may not be optimal for health.”

“A 2025 network meta-analysis of 217 randomized trials and 15,684 people with knee osteoarthritis found that aerobic exercise was likely the most beneficial exercise category for pain, function, gait, and quality of life.”

“A mouse study demonstrated that oral berberine (50 or 100 mg/kg/bw per day) reversed the depression-inducing effects of corticosterone injection by upregulating hippocampal synthesis of brain-derived neurotrophic factor – a type of protein that acts on neurons in the central and peripheral nervous systems and may be important for the antidepressant response.”

“A healthy intestinal barrier limits the transport of pathogens and endotoxins from the gut to the bloodstream; however, increased gut permeability (known as "leaky gut") raises endotoxin levels, leading to metabolic endotoxemia.”

“Many studies suggest that short-chain fatty acids derived from the gut microbiota promote the expansion of T-regulatory cells, maintain gut barrier function, regulate cytokine production, and support immune cell populations.”

“Specific topics include autophagy, the process of recycling dysfunctional cells that is induced by fasting and fasting-mimicking drugs such as resveratrol and spermidine. Rhonda discusses the effects of fasting on Parkinson's disease and which groups of people should not fast.”

“If you rapidly start a ketogenic diet, you are more likely to experience side effects including disrupted sleep and lipid abnormalities. Dr. D'Agostino asserts that transitioning to the diet by titrating carbohydrates down gradually improves adherence and tolerance.”

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.