“A healthy intestinal barrier limits the transport of pathogens and endotoxins from the gut to the bloodstream; however, increased gut permeability (known as "leaky gut") raises endotoxin levels, leading to metabolic endotoxemia.”
“The immune system has strategies for filtering these autoimmune cells out of circulation; however, this filter can malfunction due to age, genetic predisposition, disruption of the gut barrier and gut microbiota, or other environmental exposures.”
“Exercise is a huge driver of how well we age because it induces profound molecular shifts that support immune health and might even protect our telomeres – indicators of aging. Exercise might help forestall certain age-related diseases, such as Parkinson's disease, too.”
“Roughly one-quarter of people living in the US carry a genetic variant of the apolipoprotein E gene, called APOE4, the most important genetic risk factor for Alzheimer's disease. Many lifestyle behaviors can mitigate risk, especially sleep hygiene, which provides an opportunity to rid the brain of toxic metabolic byproducts that can contribute to Alzheimer's disease risk.”
“Dietary fiber is a broad term that refers to the non-digestible components of fruits and vegetables. Gut microbes break down certain types of fiber, releasing micronutrients trapped in the fiber matrix and producing beneficial metabolic byproducts, such as short-chain fatty acids.”
“Choline is particularly important during pregnancy and breastfeeding, but some evidence suggests that choline supplementation could carry some risks. In this Aliquot, I talk about the science surrounding choline.”
“In part one of this two-part Aliquot, Dr. Stuart Phillips and I talk about the role of nutrients and supplements in promoting muscle protein synthesis and subsequent increases in muscle mass and strength.”
“Meditation is a form of mental training geared toward improving aspects of a person's core neurocognitive function, such as the regulation of attention and emotion. Research suggests that meditation may protect the brain from the negative effects of stress and promote mental health.”
“Meditation, in its various forms, has powerful effects on the brain and body. In this second part of our two-part series on meditation, we'll discuss some of the different ways to engage in meditation as well as some of its parallel practices, such as running or communing with nature.”
“Migraine is a neurological disorder that typically manifests as an intense, debilitating headache and is often accompanied by nausea, vomiting, and light sensitivity. Roughly 15 percent of people worldwide experience migraines, with women reporting them more often than men.”