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“In a study where 24 middle-aged healthy dogs received either a placebo or a non-immunosuppressive dose of rapamycin three times a week for ten weeks, researchers found that dogs that received the rapamycin exhibited improvements in multiple aspects of heart function, including how well the heart filled and pumped out blood.”
“Interestingly, a recent randomized controlled trial showed that pregnant women who supplemented with 600 milligrams of DHA during their third trimester had sons with larger total brain volumes, total gray matter, corpus callosum, and cortical volumes when compared to boys born to mothers who took a placebo.”
“Interestingly, repeated exposure to whole-body heat treatment through sauna use has an even more profound effect on boosting growth hormone immediately afterward: Seventeen men and women who were exposed to two one-hour sauna sessions at 80°C (176°F) dry heat (typical Finnish-style sauna) per day for seven days exhibited a 16-fold increase in growth hormone levels by the third day.”
“Senescence is a vital cellular process involved in embryonic development, wound healing, and cancer immunity; however, the accumulation of senescent cells is associated with diseases of aging such as cancer, cardiovascular disease, type 2 diabetes, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, sarcopenia, and glaucoma.”
“In addition, a randomized, placebo-controlled, double-blind trial involving people diagnosed with mild-to-moderate dementia due to Alzheimer's disease found that participants who took a resveratrol supplement twice a day (up to 1 gram) for one year exhibited reduced levels of MMP9, a neurological inflammatory marker associated with increased neurodegeneration and inflammation.”
Small vessel disease is a generic term that describes dysfunction of blood vessels that occurs with aging and contributes to cognitive decline, cardiovascular disease, frailty, and stroke.
“After taking into account other factors, including age, race/ethnicity, poverty/income, tobacco and alcohol consumption, and physical activity, the authors also found that participants with overweight and obesity were nearly four times more likely to have low serum testosterone compared to lean males, independent of SSB consumption.”
“Robust evidence from epidemiological, clinical, rodent, and in vitro studies has demonstrated that sulforaphane exhibits antioxidant and anti-inflammatory properties and may be beneficial against a wide range of chronic and acute diseases, including autism, cancer, metabolic dysfunction, and many others and may ameliorate some of the harmful effects associated with exposure to air pollution.”
Toll-like receptors are a family of pattern recognition receptors expressed on the surface of immune and other cells that play an important role in intestinal permeability and inflammaging.
“In a trial of middle-aged, low-fitness adults, urolithin A supplementation led to a 10–12% increase in lower-body muscle strength, a 10–15% increase in VO2 peak, and better performance on a 6-minute walk test, even when participants didn't engage in structured exercise training over the 4-month study.”