Related Episodes for How the benefits of exercise can be blocked by NSAIDs and high dose supplementation of antioxidants.

“In a two-year trial of 237 postmenopausal women, approximately 9 to 10 grams per day combined with resistance training and walking did not add a bone-density benefit, so its role is better framed around muscle and physical function.”

“Researchers are studying whether consumption of the exogenous ketone ester, beta-hydroxybutyrate, may confer some of the health advantages of a ketogenic diet through its activation of PPAR-alpha, a key enzyme in the fasting response.”

“A large meta-analysis found that protein supplementation improved resistance-training gains in muscle size and strength, with little additional lean-mass benefit above an estimated total intake of about 1.6 grams per kilogram per day for most participants.”

“Earlier long-term research in older male physicians found no cognitive benefit, and the main COSMOS trial did not significantly reduce invasive cancer, cardiovascular events, or mortality over a median of 3.6 years.”

“In a secondary analysis of 72 men, the combined concentration of six PFAS declined by about 8 percent within the oat beta-glucan group over four weeks, while the study did not distinguish the magnitude of change from the control group.”

“A small magnetic-resonance spectroscopy study also found that 20 grams per day for four weeks increased brain creatine by an average of about 8.7 percent, showing that brain uptake is possible but variable.”

“High energy demand is a promising research setting. In a randomized crossover study of 15 healthy adults undergoing 21 hours of sleep deprivation, a single 0.35-gram-per-kilogram dose changed cerebral energy measures and improved selected cognitive outcomes.”

“In a randomized crossover study of 15 adults, a single weight-based dose changed cerebral energy metabolites and reduced deterioration on some cognitive tasks during about 21 hours without sleep. Dr. Patrick uses 10 grams daily and sometimes takes more during travel or sleep loss.”

“A later crossover study using a lower weight-based dose found its clearest benefit in reasoning, while several memory, accuracy, fatigue, and sleepiness outcomes did not reliably improve. Routine muscle supplementation and acute sleep-loss research use different protocols.”

“In another randomized trial, advice to drink an additional 1.5 liters of water daily improved migraine-specific quality of life, even though headache-day counts did not clearly change. Selected nutrients may help some people as part of a broader prevention plan.”