Related Episodes for How Glucose and Added Sugar Relate to Testosterone and Reward Signaling

“The mast cells release pro­inflammatory cytokines and proteases that damage the gut, leading to intestinal permeability, a condition otherwise known as “leaky gut.” This leakiness allows bacteria and bacterial antigens to cross the gut’s inner layer, the epithelium, and activate even more immune cells, leading to more inflammation – a key driver in the aging process.”

“In this brief episode, we learn how restoring our dietary and sleep pattern to one that more closely syncs with those imposed by nature, especially by avoiding eating within 2-3 hours before bed and onset of melatonin production, may improve our health and potentially prolong our healthspan.”

“Another randomized study found better long-term picture-location memory when exercise occurred four hours after learning, showing that timing can shape the result. Dr. Patrick also discusses serotonin and hippocampal neurogenesis as a possible biological link.”

Dr. Michael Snyder discusses personalized medicine and the use of technologies that monitor metabolism and other health markers.

“While Dr. Rhonda Patrick’s first video focused primarily on the micronutrients found in the various fruits and vegetables she put in her smoothie, this one, in addition to offering some modest changes on the recipe, instead focuses on the beneficial “hormetic” compounds that are NOT micronutrients.”

“A meta-analysis of resistance-training trials found that protein supplementation produced modest additional gains in strength and fat-free mass, with average fat-free-mass benefit plateauing near 1.62 g/kg/day. This is a group estimate, not a precise requirement for every older adult.”

“In turn, cellular levels of nicotinamide adenine dinucleotide, or NAD+, a coenzyme that participates in the production of cellular energy, rise, switching on energy-generating pathways and activating enzymes such as sirtuins.”

“People who have narcolepsy, a chronic neurological disorder, experience very irregular sleep-wake cycles and may fall asleep during routine daily activities such as driving or troubleshooting a difficult problem.”

“Vitamin D, like other steroid hormones, can enter a cell's nucleus and regulate numerous genes. Vitamin D serves as a major regulator of immune function and may play a particularly important role in preventing respiratory tract infections.”

“Dr. Patrick therefore favors lower-risk tools for focus, including high-quality sleep, exercise, cocoa flavanols, deliberate cold exposure, and modest caffeine, before considering an addictive stimulant. Nicotine is not equivalent to tobacco smoke, but that does not make chronic use benign.”