Mitochondrial use of fatty acids as mechanism for cancer cell death during fasting | Valter Longo

Parent Episode: Valter Longo, Ph.D. on the Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis

Fasting can have a multi-level effect in helping the body rid itself of cancer cells. During fasting, once the available glucose has been depleted, cancer cells must obtain their energy from fat. As this is not their preferred metabolic pathway, they become desperate, leading some cells to die. Furthermore, the cancer cells become more immunogenic, capable of provoking an immune response. Fasting can also alter proteins on the surface of cancer cells which normally allow them to hide from the immune system. In essence, fasting makes cancer cells less able to escape detection by the immune system. In this clip, Dr. Valter Longo explains how the use of fatty acids instead of glucose not only weakens cancer cells but also makes them more susceptible to being cleared by the immune system.

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