Related Episodes for Will intermittent fasting affect human lifespan? | Dr. Mark Mattson

“When produced during exercise (especially high intensity workouts like cycling, which shifts metabolism toward glycolysis to more quickly meet the high energetic demands), lactate switches on more than 600 genes involved in muscle adaptation, stimulates mitochondrial biogenesis – the process of making new mitochondria – and promotes protein synthesis, which is essential for muscle growth.”

“Dr. Patrick then prioritizes lower-glycemic-load, less-refined foods and adequate fiber. Early time-restricted eating can help some people reduce calories and may influence selected metabolic markers, but it is not required and must still preserve protein and diet quality.”

“Unlike antibody treatments that target the PCSK9 protein (an important regulator of blood cholesterol levels), which are very expensive, base editing could deliver permanent protection from hypercholesterolemia with just one dose.”

“For people seeking better-supported ways to improve inflammatory health, she points to regular exercise, marine omega-3 intake, and sulforaphane-rich foods as practical areas with a larger human evidence base.”

“In this clip from Dr. Rhonda Patrick's appearance on The Mel Robbins Podcast, she outlines a practical sleep audit built around adequate sleep, morning light, regular timing, earlier meals, and alcohol awareness.”

“Dr. Rhonda Patrick talks at SF Nerd Nite about transgenerational effects of caloric restriction on longevity, B-vitamins silencing bad genes, cognitive stimulation reversing neurodegenerative disease, exercise increases neurogenesis, and ways in which vitamin D might influence aging.”

“Translating sleep insights into practical steps These findings highlight the possibility of using heat therapy or vigorous exercise to influence slow-wave sleep, drawing on the interplay between body temperature regulation, immunity, physical activity, and hormones.”

“In this clip from Dr. Rhonda Patrick's conversation with Derek from More Plates More Dates, she explains how progressive endurance training can improve VO2 max and the heart's ability to fill with blood.”

“A systematic review found no overall improvement in mood after cold-water immersion, while a small randomized trial found that repeated whole-body cryotherapy improved depression scores when added to standard pharmacological treatment.”

“A single 0.35-gram-per-kilogram dose of creatine monohydrate, equal to 24.5 grams for a 70-kilogram adult, reduced fatigue and improved word memory and processing speed on selected tasks versus placebo. It also changed brain-energy measures.”