Related Episodes for MTHFR gene and supplementation with 5-L-methylfolate | Tim Ferriss

“A large meta-analysis found that protein supplementation improved resistance-training gains in muscle size and strength, with little additional lean-mass benefit above an estimated total intake of about 1.6 grams per kilogram per day for most participants.”

“Geneticists like Dr. George Church, believe gene drives could be used to eliminate pathogens carried by insects, such as malaria, which is carried by a small number of mosquito species, or Lyme disease, which is carried by deer ticks.”

“Dr. Rhonda Patrick talks at SF Nerd Nite about transgenerational effects of caloric restriction on longevity, B-vitamins silencing bad genes, cognitive stimulation reversing neurodegenerative disease, exercise increases neurogenesis, and ways in which vitamin D might influence aging.”

“Earlier long-term research in older male physicians found no cognitive benefit, and the main COSMOS trial did not significantly reduce invasive cancer, cardiovascular events, or mortality over a median of 3.6 years.”

“Studies of physician-AI collaboration show that workflow matters. In one randomized simulated-management trial, physicians using GPT-4 received higher management-reasoning scores than physicians using conventional resources, although they took longer.”

“In a secondary analysis of 72 men, the combined concentration of six PFAS declined by about 8 percent within the oat beta-glucan group over four weeks, while the study did not distinguish the magnitude of change from the control group.”

“A small magnetic-resonance spectroscopy study also found that 20 grams per day for four weeks increased brain creatine by an average of about 8.7 percent, showing that brain uptake is possible but variable.”

“High energy demand is a promising research setting. In a randomized crossover study of 15 healthy adults undergoing 21 hours of sleep deprivation, a single 0.35-gram-per-kilogram dose changed cerebral energy measures and improved selected cognitive outcomes.”

“In a randomized crossover study of 15 adults, a single weight-based dose changed cerebral energy metabolites and reduced deterioration on some cognitive tasks during about 21 hours without sleep. Dr. Patrick uses 10 grams daily and sometimes takes more during travel or sleep loss.”

“A later crossover study using a lower weight-based dose found its clearest benefit in reasoning, while several memory, accuracy, fatigue, and sleepiness outcomes did not reliably improve. Routine muscle supplementation and acute sleep-loss research use different protocols.”