Related Episodes for How NAD+ resets the circadian clock and regulates sirtuins | David Sinclair

“In this clip from Dr. Rhonda Patrick's presentation at the Vibrant Wellness Longevity Summit, she explains how the Omega-3 Index measures EPA and DHA in red-blood-cell membranes as a longer-term marker of omega-3 status.”

“Lutein and zeaxanthin also have evidence in age-related eye disease, although the AREDS2 trial did not find an additional reduction in progression to advanced macular degeneration in its primary comparison. Magnesium and creatine address different needs.”

“A meta-analysis of 49 resistance-training studies found small additional gains from protein supplementation, with fat-free-mass gains leveling near 1.6 grams per kilogram per day in the studied populations.”

“Practicing healthy light exposure habits — seeking bright light in the morning and avoiding it in the evening — is crucial. When we eat also plays a role, and eating too close to bedtime disrupts sleep and shifts circadian timing over the next few days.”

In this clip, Dr. Patrick explains how intense exercise beneficially alters tryptophan and kynurenine metabolism in a way that may benefit depression.

“Adequate, quality sleep is essential for the body's recovery and repair, promoting optimal physical and mental health. Getting a good night's sleep can be challenging, especially in our modern world, but we can take steps to overcome those challenges. In this Aliquot, we present a mashup of our best resources on sleep, featuring insights from Dr. Matthew Walker, Dr. Satchin Panda, and me.”

“Imagine a drug that improves sleep, reduces stress, sharpens focus, and boosts mood—without cost or side effects. That "drug" is light. Natural light is more than just illumination; it's a potent regulator of our body's internal clock, driving critical processes like hormone release and sleep-wake cycles.”

“In this Aliquot, I break down what the research tells us about glyphosate exposure in farming communities versus the general population, explore how it may lead to DNA damage, and share practical strategies for reducing exposure—starting with your grocery list.”

“In this Aliquot, I'm joined by exercise-oncology researcher Dr. Kerry Courneya to identify and prioritize the lifestyle behaviors that account for much of the difference in cancer risk and have the greatest long-term impact.”

“Jet lag often shows up as fatigue after a long flight, reflecting a mismatch between your internal clock and the external world. In this Aliquot, joined by Drs. Michael Grandner and Darren Candow, I explain how jet lag works, which signals are most important for resetting your clock, and how to reduce jet lag before travel and recover more quickly after arrival.”