Related Episodes for NMN supplementation reduced aging in mice (broad array of parameters) | David Sinclair

“As research progresses, my dietary and supplement habits adapt. At times, it's the ineffable quality of consciousness, submerged in a mental calculus of cost-benefits, that nudges a change of heart. Other times, it's the stark contradiction of new data that compels a shift.”

“A four-week pilot study in people with type 2 diabetes reported improved insulin-stimulated glucose disposal after oral alpha-lipoic acid, while a three-week randomized trial found that intravenous 600 milligrams per day reduced diabetic neuropathy symptoms.”

“Because of alcohol’s effect on other organs and the evidence that any dose of alcohol appears to elevate cancer risk, Dr. Huberman thinks that zero to two drinks per week represents a “safe zone” as long as you’re of age, not pregnant, and not an alcoholic.”

“According to the latest research on fed vs. fasted exercise: If your workout lasts longer than 60 minutes, especially aerobic (endurance-based) sessions, eating beforehand tends to improve performance Your body has quick access to glucose, which helps you go longer and harder.”

“In this FoundMyFitness interview clip with Dr. Rhonda Patrick, Dr. Layne Norton places creatine monohydrate in his highest evidence tier because it supports repeated high-intensity performance, strength, and gains in lean mass.”

“However, she considers the amounts in its proprietary superfood, extract, and probiotic blends too small to justify expecting the broader benefits implied by those categories. She presents this as her assessment of the product label.”

“In a separate analysis of seven intervention trials involving people with type 2 diabetes, HbA1c fell by about 0.71 percentage points, total cholesterol by 23 mg/dL, and LDL cholesterol by 22 mg/dL.”

“In a six-month trial of adults with peripheral artery disease, a flavanol-rich cocoa beverage improved six-minute walking distance measured 2.5 hours after dosing. In older adults with mild cognitive impairment, higher-flavanol cocoa improved selected verbal-fluency and executive-function tests over eight weeks.”

“The majority of glutamine administered orally is taken up by the liver and gut, with little ending up in the bloodstream. Dr. D'Agostino discourages supplementing with glutamine for patients with cancers of the gastrointestinal tract and even recommends they avoid high glutamine containing foods.”

“Dr. Patrick explains that she uses zinc lozenges only during exposure or the earliest signs of illness, often totaling roughly 80 to 100 milligrams per day for a short period. Small randomized zinc-acetate lozenge trials have produced mixed results, with one reporting a shorter cold and another finding no faster recovery with more adverse effects.”