Related Episodes for NMN supplementation reduced aging in mice (broad array of parameters) | David Sinclair

Dr. Rhonda Patrick covers lithium microdosing, reducing homocysteine, aluminum's link to cancer, and beta-alanine and alpha-lipoic acid supplements.

“This is a personal preparation example, not the high-dose oat regimen used in clinical research or a measured 3-gram beta-glucan serving. For the research on LDL cholesterol, microbial metabolites, and oat preparation, see Oats and beta-glucan.”

Dr. Rhonda Patrick discusses iron imbalances, urolithin A, NAD+ boosters, vitamin K2 and hormone replacement therapy in women.

“The discussion of fiber and nutrient or supplement absorption begins at 19:38. The Oats and beta-glucan topic provides the wider cholesterol evidence and explains why whole oats, beta-glucan powder, and psyllium should not be compared solely by their serving weights.”

Dr. Rhonda Patrick discusses urolithin A, postmenopausal protein, microplastics, high-temperature saunas, sugar intake, and supplements for Parkinson's disease.

“Human trials suggest that alpha-lipoic acid can modestly improve selected lipid measures. A dose-response meta-analysis of 12 studies found reductions in total cholesterol, LDL cholesterol, and triglycerides across doses from 300 to 1,200 milligrams per day.”

“But evidence suggests that supplemental vitamin D in lactating women can increase breast milk concentrations to levels that are adequate to reduce the risk of deficiency in breastfed infants. In this clip, Dr. Rhonda Patrick describes the data suggesting that maternal supplemental vitamin D can reduce the risk of deficiency in breastfed infants.”

“Similarly, the timing of eating and exercise, especially in elite athletes, has not been studied and may, in fact, require self-experimentation by the athletes as they find the perfect interval of fasting to support their optimal performance.”

“A 12-month randomized controlled trial found that vitamin D supplementation improved cognitive function, intelligence quotient scores, telomere length, and lowered oxidative stress markers in older adults with mild cognitive impairment (compared to placebo), suggesting that not only does vitamin D supplementation improve biomarkers of aging, but also functional outcomes.”

“A 2025 meta-analysis found improved quality of life, no clear overall change in ejection fraction, and a borderline improvement in New York Heart Association functional class across a small set of trials.”