Related Episodes for Reduction of inflammation from sulforaphane supplementation as a treatment for depression | Jed Fahey

“Dr. van Loon sees useful research questions in skin, joints, and recovery after orthopedic surgery, but he keeps those possibilities separate from established muscle-building effects.”

“Dr. Rhonda Patrick discusses how conditioning the body to heat stress through sauna use, called "hyperthermic conditioning" may cause adaptations that increase athletic endurance (by increasing plasma volume and blood flow to heart and muscles) and potentially even muscle mass. She also discusses the profound effects of hyperthermic conditioning on the brain including cognitive function.”

“Fasting can deplete the body's stores of electrolytes, especially during prolonged fasts or during periods of exercise when electrolytes can be lost during sweat. Because electrolytes are non-calories, replenishment does not appear to alter circadian rhythms.”

“While it’s likely that there may be more going on with depression than just inflammation by itself, it could be an incredibly useful lens through which to look at promising avenues to potentially treat or prevent it, since controlling systemic inflammation shows promise as being both important for longevity and health in general.”

“While this system might have served an important function evolutionarily, today it contributes to the chronic inflammation associated with heart disease. In this clip, Dr. Ronald Krauss discusses the role of inflammation in lipoprotein metabolism.”

“Circulating LPS can also bind to lipoproteins, facilitating their absorption in the liver during LDL recycling, effectively removing LPS from circulation and lowering systemic inflammation – a phenomenon demonstrated mechanistically with statins that increase lipoprotein recycling by increasing LDL receptors.”

“00:34:40 - Repeated traumatic brain injury has cumulative neuroinflammatory effects in the brain over years, including amyloid-beta plaque and tau tangle formation. Study. 00:44:00 - A variant of the APOE gene increases risk of developing Alzheimer’s disease as much as 15-fold.”

“Dr. Patrick also discusses glucose, HbA1c, fasting insulin, kidney and electrolyte markers, hs-CRP, fibrinogen, thyroid tests, CBC, vitamin D, sex hormones, IGF-1, and the Omega-3 Index.”

“People who have poor cardiorespiratory fitness are more likely to be depressed. Sauna improves cardiorespiratory fitness and may offer a means to ameliorate the symptoms of depression and improve mood. In this clip, Drs. Rhonda Patrick and Jari Laukkanen discuss the benefits of sauna use in terms of cardiorespiratory fitness and mood.”

“A higher omega-3-index quintile was associated with lower all-cause mortality risk, but the estimated years of life were model-derived comparisons between quintiles, not observed gains from raising an index from 4% to 8%.”