Related Episodes for The evolutionary advantage to depression (and sickness behavior) | Charles Raison

“Resveratrol, a plant-based compound found in red grapes and peanuts, has been shown to exert beneficial health effects – especially on the cardiovascular system of monkeys. Resveratrol is a "dirty molecule," however, known for its multiple cellular targets, so teasing out all the ramifications of its use has proven problematic.”

“Her practical message is to reduce the frequency and size of large glucose exposures. Foods with intact fiber, protein, and minimally processed carbohydrates digest more slowly than refined added sugar, while regular exercise gives skeletal muscle a large destination for circulating glucose.”

“In this clip from Dr. Rhonda Patrick's appearance on Modern Wisdom, she explains how a large post-meal glucose rise and fall can contribute to the sluggish feeling people call brain fog. Food order offers one practical lever.”

“A smaller comparative study found improved hair density, shaft size, and anagen-follicle proportion with 2 percent ketoconazole shampoo, while its authors called for larger controlled studies. These results support individualized combinations rather than one universal protocol.”

“Dr. Mattson contends that unstressed cells become complacent, making them more vulnerable to the stressors that cause disease, including oxidative stress and inflammation. In modern times, fasting and exercise are behaviors that mildly stress cells.”

“Patients assigned to supervised exercise during neoadjuvant chemoradiation, followed by continued activity before surgery, were more likely to achieve a complete or near-complete pathological response than those receiving usual care.”

“The end result is an upside-down sleep schedule in which circadian rhythms and gene expression in the body become desynchronized. In this clip, Dr. Satchin Panda describes the effects of inappropriate light signals and discusses strategies to mitigate their effects.”

“Studies of centenarians suggest that lower levels of inflammation are associated with longevity. Different types of fiber provide fuel to diverse species of bacteria in the gut, which then synthesize byproducts that regulate the inflammatory process.”

“In this clip, Drs. Levine and Patrick discuss genetic and environmental factors that can accelerate or slow epigenetic aging. Dr. Levine also discusses the aging clock she created and how it can be used, along with other biomarkers, to determine an individual's rate of aging.”

“In the modern-day with no imposed fasting, these cycles of renewal may remain dormant. In this clip, Dr. Valter Longo discusses how cellular repair mechanisms may have evolved during times of fasting, but are latent in times of food abundance.”