Related Episodes for Jed Fahey, ScD, on Isothiocyanates, the Nrf2 Pathway, Moringa, & Sulforaphane Supplementation

“When produced during exercise (especially high intensity workouts like cycling, which shifts metabolism toward glycolysis to more quickly meet the high energetic demands), lactate switches on more than 600 genes involved in muscle adaptation, stimulates mitochondrial biogenesis – the process of making new mitochondria – and promotes protein synthesis, which is essential for muscle growth.”

“How too much iron can lead to protein aggregation and how vitamin D can prevent it. A program, directed by Gordon, called the Caenorhabditis Intervention Testing Program which tests potential longevity compounds that may extend the lifespan of several different species of worms.”

“Dr. Rhonda Patrick talks at SF Nerd Nite about transgenerational effects of caloric restriction on longevity, B-vitamins silencing bad genes, cognitive stimulation reversing neurodegenerative disease, exercise increases neurogenesis, and ways in which vitamin D might influence aging.”

“Translating sleep insights into practical steps These findings highlight the possibility of using heat therapy or vigorous exercise to influence slow-wave sleep, drawing on the interplay between body temperature regulation, immunity, physical activity, and hormones.”

“Earlier long-term research in older male physicians found no cognitive benefit, and the main COSMOS trial did not significantly reduce invasive cancer, cardiovascular events, or mortality over a median of 3.6 years.”

“In a secondary analysis of 72 men, the combined concentration of six PFAS declined by about 8 percent within the oat beta-glucan group over four weeks, while the study did not distinguish the magnitude of change from the control group.”

“High energy demand is a promising research setting. In a randomized crossover study of 15 healthy adults undergoing 21 hours of sleep deprivation, a single 0.35-gram-per-kilogram dose changed cerebral energy measures and improved selected cognitive outcomes.”

“A later crossover study using a lower weight-based dose found its clearest benefit in reasoning, while several memory, accuracy, fatigue, and sleepiness outcomes did not reliably improve. Routine muscle supplementation and acute sleep-loss research use different protocols.”

“Visceral fat can respond to changes in energy balance and physical activity. A meta-analysis of 40 randomized trials and 2,190 adults with overweight or obesity found that both exercise and calorie restriction reduced CT- or MRI-measured visceral fat.”

“A systematic review in older adults linked Mediterranean dietary patterns with lower inflammatory markers, while a meta-analysis of randomized trials found that vitamin D supplementation reduced acute respiratory infection risk overall, with the strongest protection among people who were very deficient and received regular doses.”