Related Episodes for Peter Attia, M.D. on Macronutrient Thresholds for Longevity and Performance, Cancer & More

“- Arthur Brooks, Ph.D. The episode closes with a framework from Brooks's work on the second half of life: jump, serve, worship, and connect, a framework he outlines in one of his earlier books, From Strength to Strength: "Jump" means proactively building the next thing, especially during liminal periods or unwelcome change, which Brooks sees as fertile ground for creativity.”

“Since a driving force in the development of insomnia is change, especially change that affects relationships, employment, or family dynamics, Dr. Mason employs cognitive behavior techniques that help her patients identify what those changes are and develop strategies that promote, rather than hinder, sleep.”

“Dr. Aubrey de Grey is a biomedical gerontologist and the founder of the SENS Research Foundation which aims to find technologies that can repair the various types of damage that occur during the aging process. Learn more about Dr. Aubrey De Grey SENS Research Foundation.”

“Activation of this important system of immunosurveillance is a predictor of the long-term efficacy of chemotherapy and may help to explain the complex relationship of autophagy with cancer, wherein the initial suppression of autophagy may help prevent attracting undue attention from the immune system, but may later facilitate ongoing transformation.”

“Researchers have determined that beta-hydroxybutyrate is an endogenous regulator of HDACs and is able to regulate age-related genes such as FOXO3. In this clip, Dr. Eric Verdin discusses the role of beta-hydroxybutyrate in protecting against oxidative stress, both as a nutrient, but also as a transcription regulator.”

“For instance, while the U.S. has high obesity rates, its rates of type 2 diabetes remain modest compared to countries like Singapore, India, and many Middle Eastern nations—populations that, on average, tend to have "fatter fat cells" and therefore develop metabolic complications at lower body mass indices (BMIs).”

“Breast milk contains a diverse and highly complex community of microbes that come from a variety of sources. Exposure to this community may contribute to the differences observed in gut microbial populations between breastfed and formula-fed infants. In this clip, Dr. Rhonda Patrick describes the unique community of microbes present in human breast milk.”

“Practicing the skills they acquire with resources available in the community — a personal trainer or a group class will allow them to reap the benefits of exercise. People are encouraged to try a variety of activities, which can improve their enjoyment and compliance.”

“Another study suggests that intermittent fasting combined with exercise training increased serum ketone levels, increased the number of mitochondria in muscle cells, and improved endurance. In this clip, Dr. Mark Mattson describes how fasting and exercise work together to promote brain health.”

“Dr. Patrick treats magnesium L-threonate separately. Early human findings are limited by small studies, industry funding, and products that sometimes include coingredients, making it difficult to attribute effects to L-threonate alone.”