Search results for mitochondria

“In this excerpt from Dr. Rhonda Patrick’s A4M LongevityFest 2023 keynote, she reviews a randomized trial in sedentary middle-aged adults. Two years of progressive, supervised aerobic training increased VO2 max and reduced left-ventricular stiffness.”

“Premenopausal females have much lower rates of cardiovascular disease than similarly aged males because of the protective effects of estrogen, but after menopause, there's not much of a difference, and cardiometabolic risk factors actually worsen in females during the menopause transition, indicating this may be a crucial time for exercise intervention to protect the cardiovascular system.”

“Older men and women that supplemented 500 mg of resveratrol a day combined with aerobic and resistance exercise for 12 weeks improved mitochondrial density and muscle fatigue and had a 45.3% increase in muscle fiber area and a 20% increase in total muscle fiber myonuclei compared to men in the placebo group.”

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

“The impact of the ketogenic diet on gut bacteria has not been actively studied. In animal models high-fat diets are thought to provoke the release of endotoxin from bacterial cell membranes resulting in negative health consequences. In this clip, Dr. Dominic D'Agostino and Dr. Rhonda Patrick discuss the ketogenic diet and its implications for gut health.”

“At the same time, mitochondrial biogenesis increases, and reactive oxygen species and inflammatory cytokines decrease. In this clip, Dr. Dominic D'Agostino discusses how the body adapts to a ketogenic diet and the possible impacts on age-related chronic diseases.”

“A new study found that daily heat treatments applied locally to muscle during 10 days of immobilization prevented the loss of mitochondrial function, increased heat shock protein levels, and attenuated skeletal muscle atrophy by 37% compared to sham control in a small trial in humans.”

“In animal models, mice fed a medium-chain triglyceride supplemented ketogenic diet ran farther and faster on a treadmill than animals fed standard chow. In humans, the data supporting the benefit of ketones on performance are less clear.”

“In a randomized crossover trial, a standardized ashwagandha extract produced a modest testosterone increase in overweight men with mild fatigue, while a meta-analysis of five tongkat ali trials found a positive pooled effect with substantial variation across studies.”

“Sprint-interval exercise improved reaction time on selected executive-function tasks for about 10 to 30 minutes in a controlled study, supporting Dr. Patrick's practice of using a short workout before an early talk or demanding meeting.”