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Dr. Rhonda Patrick reviews the evidence for nattokinase, how oat beta-glucans may aid with PFAS excretion, and HRT for APOE4 carriers.

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

“When this barrier breaks down, as in, intestinal permeability, also known as "leaky gut," microbes and their metabolites translocate out of the intestinal lumen and influence the health and function of distant tissues, such as the brain, connective tissues, sometimes promoting a state known as "metabolic endotoxemia."”

“Use of these substances is often carried out in a highly controlled cultural context for religious or healing purposes or for divination and not casual use. The use is often accompanied by strong mystical experiences that have great significance to the user.”

“For people who begin in their seventies, Dr. Levine says exercise can still lower blood pressure, improve endothelial function, alter autonomic control, and raise VO2 max even when structural remodeling of the heart is limited.”

“Pooled intervention data suggest that about 1.5 to 2 grams of combined EPA and DHA per day can raise the Omega-3 Index in many adults over several months, although individual responses vary.”

“Meditation is a form of mental training geared toward improving aspects of a person's core neurocognitive function, such as the regulation of attention and emotion. Research suggests that meditation may protect the brain from the negative effects of stress and promote mental health.”

“His research has shown that the chief culprit of atherogenic dyslipidemia is simple, refined sugar. In this clip, Dr. Ronald Krauss shares his experience in research showing heart disease risk is more influenced by sugar consumption than fat consumption.”

“Continued physical, social, and intellectual engagement offers a practical way to support multiple parts of peakspan throughout later life, while the framework helps people think about function one domain at a time.”

“Recent data from animal studies indicate that time-restricted feeding – even in overweight animals eating a poor diet – has beneficial effects on metabolic health. Studies investigating whether the same benefits will be observed in a real-world setting in humans are lacking, however.”