Related Episodes for Does meal frequency matter for time-restricted eating? | Ruth Patterson

“In this clip from his FoundMyFitness interview with Dr. Rhonda Patrick, Dr. Benjamin Levine explains why recovery is part of training rather than time lost between workouts. Hard sessions trigger protein synthesis, vascular signaling, and muscular remodeling, but those changes need lower-stress time to develop.”

“Dr. Patrick explains some of the early evidence that suggests the value prolonged fasting (48+ hours) may have from the standpoint of tissue rejuvenation and healthspan maintenance, as well as relevance for other more specific conditions.”

“Dr. Shinya Yamanaka discovered a group of proteins that can reprogram differentiated (mature) cells into pluripotent stem cells. These proteins, now called Yamanaka factors, are highly expressed in embryonic stem cells in mice and humans.”

“The body has elegant mechanisms that allow it to utilize non-carbohydrate substrates to generate glucose. Gluconeogenesis is a metabolic pathway in which the liver produces glucose from non-carbohydrate substrates including glucogenic amino acids (from protein) and glycerol (from lipids).”

“However, the DNAm GrimAge epigenetic clock is a highly reliable predictor of healthspan and lifespan, based on DNAm surrogates in blood, including biomarkers of aging and alterations in blood composition.”

“The algorithm — based on factors including blood parameters, dietary habits, and gut microbiota — was employed in a clinical trial, where researchers showed that personally tailored diets lowered post-meal blood glucose levels.”

“Studies of physician-AI collaboration show that workflow matters. In one randomized simulated-management trial, physicians using GPT-4 received higher management-reasoning scores than physicians using conventional resources, although they took longer.”

“In this clip from Dr. Rhonda Patrick's appearance on The Diary of a CEO, she explains that a shorter eating window can make calorie reduction easier, while a longer overnight fast shifts fuel use toward fatty acids and ketones.”

“In a 7.5-week randomized trial of 39 adults with overweight or obesity, a 13-to-16-hour overnight fast that ended food intake at least three hours before habitual sleep improved nighttime diastolic blood-pressure dipping by about 3.5 percent and lowered nighttime diastolic pressure by about 1.8 mm Hg.”

“Mouse studies of feeding during infection also found different responses across bacterial and viral models, so a minimally processed dietary pattern, regular exercise, and normal hydration and nutrition during illness provide a more useful foundation than one universal food or fasting rule.”