Related Episodes for How time-restricted eating affects leaky gut and systemic inflammation | Satchin Panda

“Normalizing the timing of food intake via time-restricted eating may help restore microbiome composition, potentially offsetting the increased disease risk. In this clip, Dr. Eran Elinav describes how the circadian rhythmicity of the microbiome is regulated and how this affects human health.”

“In conjunction with a restricted eating window, meal frequency can also play a role. Two meals a day may be optimal for individuals who are predisposed to gaining weight while people not prone to weight gain may prefer to eat three times a day.”

“A 2025 meta-analysis found improved quality of life, no clear overall change in ejection fraction, and a borderline improvement in New York Heart Association functional class across a small set of trials.”

“In a controlled five-week crossover trial involving men with prediabetes, an early six-hour eating window with dinner before 3 p.m. improved insulin sensitivity, pancreatic beta-cell responsiveness, blood pressure, oxidative stress, and appetite without causing weight loss.”

“In this Aliquot, along with Dr. Eran Elinav, I explore how gluten affects the gut barrier, who actually needs to avoid it, and the practical strategies that can help you build a more resilient gut.”

“In this Aliquot, I explain why visceral fat behaves so differently from other fat, how it drives insulin resistance and chronic disease, and what research shows about the most effective ways to reduce it.”

“As for this last point in particular, but also all conversations surrounding severe life-altering diagnosis like cancer, these clips are not meant to serve as a substitute for medical advice.”

“The timing of eating and exercise, especially in elite athletes, hasn't been studied and may, in fact, require self-experimentation by the athletes to identify the perfect interval of fasting to support their optimal performance.”

“Diet stands out as low-hanging fruit for influencing our lifespan. Optimizing macronutrient intake, practicing time-restricted eating, and consuming healthful bioactive compounds are critical aspects of a healthy diet. In part II of this two-part Aliquot, Drs.”

“A healthy intestinal barrier limits the transport of pathogens and endotoxins from the gut to the bloodstream; however, increased gut permeability (known as "leaky gut") raises endotoxin levels, leading to metabolic endotoxemia.”