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“A small one-year randomized trial in older adults appeared to buffer decline on a verbal-learning task and increased activation in selected frontal regions; the result needs replication and does not establish broad cognitive enhancement.”

“The main ingredient-interaction evidence concerns polyphenol oxidase. A small controlled crossover study found that a high-PPO banana smoothie greatly reduced circulating flavan-3-ol metabolites compared with a low-PPO berry drink or capsule control.”

Dr. Rhonda Patrick discusses organic produce, fasting-mimicking diets, sleep, sauna, sunscreens, red light therapy, reverse osmosis water, and fiber.

“Scientists are exploring a wide range of cutting-edge therapies aimed at understanding and manipulating the complex processes underlying these hallmarks, including epigenetic aging clocks and pluripotent stem cells.”

“Advanced glycation end-products, or AGEs for short, are created when the sugars, amino acids, and fats in food encounter heat. AGEs also form in the body during normal glucose metabolism. However, if high levels of AGEs accumulate in the tissues and blood, they can become pathogenic.”

“In this FoundMyFitness Premium Q&A preview, Dr. Rhonda Patrick reviews common contributors to fragmented sleep, including insomnia, sleep apnea, nocturia, psychological stress, irregular schedules, caffeine, alcohol, light, noise, temperature, and late eating.”

“Dr. Huberman delays his first meal until late morning, then uses protein-rich whole foods, fruit, vegetables, and starches according to training and appetite. His core supplements include omega-3s, vitamin D, vitamin K2, and selected products guided by his own response and blood work.”

“Preventing dementia requires a lifelong and multipronged approach that involves keeping inflammation (and its aging effects) at bay and making healthy lifestyle choices, such as exercising and consuming omega-3 fatty acids.”

“Dr. Huberman contrasts these with effortful pursuits, but this is a conceptual analogy rather than evidence that screens or color produce drug-equivalent dopamine changes. Large peaks can be followed by reduced drive while signaling recovers.”

Dr. Rhonda Patrick reviews the evidence for nattokinase, how oat beta-glucans may aid with PFAS excretion, and HRT for APOE4 carriers.