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Dr. Rhonda Patrick discusses joint aging prevention, avoiding heavy metals in protein, reducing migraines, nicotinamide for skin, and minimizing jet lag.

“As a founding principal investigator at Altos Lab, Dr. Levine sits at the frontier of aging research, where she and her colleagues are investigating what she describes as some of the most exciting research in the field, centered on interrupted cellular reprogramming.”

“Authors of a 2021 study recruited 50 participants (between ages 18 and 75 years) who were not consuming dietary supplements or large quantities of olive oil (greater than one tablespoon per day).”

“Another study in which 22 year old men who engaged in four weeks of high-intensity interval training three days a week and supplemented with 150 milligrams of resveratrol per day, the lowest dose of the studies mentioned so far, did not promote increases in the men's aerobic or anaerobic capacity, exercise substrate utilization, or muscle fiber-specific adaptations compared to exercise alone.”

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

“Study. 01:43:00 - High animal protein intake was only positively associated with cardiovascular mortality among individuals with at least one unhealthy lifestyle risk factor, such as obesity or sedentary lifestyle. Study.”

“Increased intestinal permeability (also known as "leaky gut") – a condition in which gaps form between the tight junctions that join enterocytes – allows pathogens to leak through the intestinal barrier and pass directly into the bloodstream, promoting inflammation through a specialized mechanism involving detection by toll-like receptors.”

“In addition, a randomized, placebo-controlled, double-blind trial involving people diagnosed with mild-to-moderate dementia due to Alzheimer's disease found that participants who took a resveratrol supplement twice a day (up to 1 gram) for one year exhibited reduced levels of MMP9, a neurological inflammatory marker associated with increased neurodegeneration and inflammation.”

“Caloric restriction, a potent inducer of autophagy, extends lifespan in many organisms but also reduces the risk of many age-related chronic diseases, such as diabetes, cardiovascular disease, cancer, and brain atrophy – likely attributable to the beneficial effects of autophagy.”

“Body surface area A simple empirical approach called allometric scaling allows a dose to be scaled and normalized based on differences in body surface area to extrapolate doses from animal science to human research, resulting in a correction factor unique to the species.”